Author

R. M. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Assay:imaging· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

W. Losert· 4 shared M. I. Vitolo· 3 shared S. S. Martin· 3 shared A. A. Gad· 1 shared A. Omidvar· 1 shared C. Ling· 1 shared D. A. Annis· 1 shared D. E. Gilchrist· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiophysics

W. Losert

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Disruption of P2Y2 signaling promotes breast tumor cell dissemination by reducing ATP-dependent calcium elevation and actin localization to cell junctions

M. L. Mull, S. J. P. Pratt, K. N. Thompson, D. A. Annis, A. A. Gad, R. M. Lee, K. T. Chang, M. B. Stemberger, J. A. Ju, D. E. Gilchrist, L. Boyman, M. I. Vitolo, W. J. Lederer, S. S. Martin

This study shows that P2Y2 receptor signaling, which increases intracellular calcium and actin localization in non-tumorigenic breast cells, is disrupted in metastatic cells, promoting dissemination.

bioRxiv · Mar 31, 2023Cancer Biology

Propagation dynamics of electrotactic motility in large epithelial cell sheets

Y. Zhang, G. Xu, J. Wu, R. M. Lee, Z. Zhu, Y. Sun, K. Zhu, W. Losert, S. Liao, G. Zhang, T. Pan, Z. Xu, F. Lin, M. Zhao

The paper uses electric fields to induce migration in human keratinocyte sheets and develops an in silico model showing how directional cues propagate to drive coherent collective migration.

bioRxiv · Jul 30, 2022Cell Biology

Label-free Cell Tracking Enables Collective Motion Phenotyping in Epithelial Monolayers

S. Gu, R. M. Lee, Z. Benson, C. Ling, M. I. Vitolo, S. S. Martin, J. Chalfoun, W. Losert

The paper introduces an AI-based pipeline to track cell nuclei in phase contrast images and uses it to analyze collective motion in epithelial monolayers, finding that D2min correlates with metastatic potential.

bioRxiv · Dec 14, 2021Biophysics

Distinct Roles of Tumor-Associated Mutations in Collective Cell Migration

R. M. Lee, M. I. Vitolo, W. Losert, S. S. Martin

The paper investigates how tumor-associated mutations affect collective cell migration, finding that PTEN deletion enhances it while Ras activation suppresses it, with implications for metastasis.

Scientific Reports · May 13, 2021Peer-reviewedBiophysics

Quantifying topography-guided actin dynamics across scales using optical flow

R. M. Lee, L. Campanello, M. Hourwitz, P. Alvarez, A. Omidvar, J. T. Fourkas, W. Losert

The paper quantifies actin wave dynamics on periodic topographies using optical flow, finding similar nanotopography-guided actin behavior in two cell types despite differences in wave speed and morphology.

bioRxiv · Sep 3, 2019Biophysics