Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection
P. Ghorbani, S. Y. Kim, T. K. Smith, L. Minarrieta, V. Robert-Gostlin, M. K. Kilgour, M. Ilijevska, I. Alecu, S. A. Snider, K. D. Margison, J. R. Nunes, D. Woo, C. Pember, C. O'Dwyer, J. Ouellette, , M. D. Fullerton
This study shows that choline metabolism is essential for IL-4-induced macrophage polarization and RELMα expression during helminth infection, affecting immune homeostasis and parasite clearance.
bioRxiv · Sep 30, 2022 · PreprintImmunology