Author

K. D. Margison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

C. O'Dwyer· 2 shared J. R. Nunes· 2 shared M. D. Fullerton· 2 shared P. Ghorbani· 2 shared A. Blais· 1 shared B. Lacoste· 1 shared C. Pember· 1 shared D. Woo· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

C. O'Dwyer

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection

P. Ghorbani, S. Y. Kim, T. K. Smith, L. Minarrieta, V. Robert-Gostlin, M. K. Kilgour, M. Ilijevska, I. Alecu, S. A. Snider, K. D. Margison, J. R. Nunes, D. Woo, C. Pember, C. O'Dwyer, J. Ouellette, , M. D. Fullerton

This study shows that choline metabolism is essential for IL-4-induced macrophage polarization and RELMα expression during helminth infection, affecting immune homeostasis and parasite clearance.

bioRxiv · Sep 30, 2022 · PreprintImmunology

Fatty acid-induced lipotoxicity inhibits choline metabolism independent of ER stress in mouse primary hepatocytes

C. O'Dwyer, R. Yaworski, N. D. LeBlond, P. Ghorbani, J. R. Nunes, K. D. Margison, T. T. Smith, K. Gobeil Odai, S. Han, M. D. Fullerton

This study shows that fatty acid-induced lipotoxicity reduces choline uptake and PC synthesis in mouse hepatocytes, independent of ER stress.

bioRxiv · Aug 25, 2019 · PreprintCell Biology