Author

J. R. Nunes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

C. O'Dwyer· 4 shared M. D. Fullerton· 4 shared P. Ghorbani· 4 shared T. K. Smith· 3 shared C. Pember· 2 shared E. E. Mulvihill· 2 shared K. D. Margison· 2 shared M. K. Kilgour· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersPhysiology

C. O'Dwyer

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Author profile →

4 papers

Recent·Most cited

Thermoneutral housing does not accelerate metabolic dysfunction-associated fatty liver disease in male or female mice fed a Western diet

J. R. Nunes, T. K. Smith, P. Ghorbani, C. O'Dwyer, N. A. Trzaskalski, H. Dergham, C. Pember, M. K. Kilgour, E. E. Mulvihill, M. D. Fullerton

This study investigates whether thermoneutral housing accelerates MAFLD in mice fed a Western diet, finding no significant acceleration in disease progression despite sex-specific metabolic effects.

bioRxiv · Jan 24, 2023 · PreprintPhysiology

Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection

P. Ghorbani, S. Y. Kim, T. K. Smith, L. Minarrieta, V. Robert-Gostlin, M. K. Kilgour, M. Ilijevska, I. Alecu, S. A. Snider, K. D. Margison, J. R. Nunes, D. Woo, C. Pember, C. O'Dwyer, J. Ouellette, , M. D. Fullerton

This study shows that choline metabolism is essential for IL-4-induced macrophage polarization and RELMα expression during helminth infection, affecting immune homeostasis and parasite clearance.

bioRxiv · Sep 30, 2022 · PreprintImmunology

Myeloid deletion and therapeutic activation of AMP-activated protein kinase (AMPK) do not alter atherosclerosis in male or female mice

N. D. LeBlond, P. Ghorbani, C. O'Dwyer, N. Ambursley, J. R. Nunes, T. K. Smith, N. A. Trzaskalski, E. E. Mulvihill, V. Benoit, M. Foretz, M. D. Fullerton

This study shows that deleting AMPK in myeloid cells or activating it therapeutically does not affect atherosclerosis in male or female mice.

bioRxiv · Jul 15, 2020 · PreprintBiochemistry

Fatty acid-induced lipotoxicity inhibits choline metabolism independent of ER stress in mouse primary hepatocytes

C. O'Dwyer, R. Yaworski, N. D. LeBlond, P. Ghorbani, J. R. Nunes, K. D. Margison, T. T. Smith, K. Gobeil Odai, S. Han, M. D. Fullerton

This study shows that fatty acid-induced lipotoxicity reduces choline uptake and PC synthesis in mouse hepatocytes, independent of ER stress.

bioRxiv · Aug 25, 2019 · PreprintCell Biology