Dose-response relationship for the resistance of human insulin to degradation by insulin-degrading enzyme
M. Okumura, T. Kuramochi, Y. Lin, R. Furukawa, K. Mizutani, T. Yokoyama, M. Kim, M. H. Lim, H.-S. Yi, K. Arai, H. Yamaguchi, H. Hojo, M. Iwaoka, Y. Tanaka, S.-Y. Park, , Y.-H. Lee
The paper investigates how human insulin resistance to degradation by IDE varies with dose and identifies structural features of the insulin hexamer that influence degradation kinetics without zinc.
bioRxiv · Apr 8, 2023 · PreprintBiochemistry