K. Inaba

A sequential, RNA-derived, modified adenosine pathway safeguards cellular metabolism

The paper shows that modified adenosines from RNA catabolism are sequentially metabolized to prevent toxicity and maintain metabolic balance.

Glutathione supersulphide regulates T-cell receptor signalling

This study shows that glutathione supersulphide regulates T-cell receptor signalling by interacting with the CD3ε chain, affecting TCR activation and inflammation.

Convergent reductive evolution of cyanobacteria in symbiosis with Dinophysiales dinoflagellates

This study sequenced a cyanobacterial symbiont of a dinoflagellate, revealing convergent genome reduction and shared features with another symbiont, while identifying unique genomic islands.

Deciphering the Genomes of Motility-Deficient Mutants of Vibrio alginolyticus 138-2

This study identifies mutations in flagella-related genes in motility-deficient Vibrio alginolyticus mutants through genomic analysis.

Structure of full-length ERGIC-53 in complex with MCFD2 for cargo transport

This study determines the cryo-EM structure of full-length ERGIC-53 complexed with MCFD2, revealing its tetrameric architecture and mechanism of cargo transport.

Dose-response relationship for the resistance of human insulin to degradation by insulin-degrading enzyme

The paper investigates how human insulin resistance to degradation by IDE varies with dose and identifies structural features of the insulin hexamer that influence degradation kinetics without zinc.

"Two-story building" of a ctenophore comb plate provides structural and functional integrity for motility of giant multicilia

The paper identifies a second component of ctenophore comb plate compartmenting lamella, CTENO189, and shows its role in maintaining ciliary coordination and motility.

Distinct roles and actions of PDI family enzymes in catalysis of nascent-chain disulfide formation

This study compares the efficiency of PDI and ERp46 in catalyzing disulfide bond formation in nascent chains during translation, showing ERp46 is more effective early on.

A unique adhesive motif of protein disulfide isomerase P5 supports its function via dimerization

This study identifies a unique adhesive motif in P5 that enables dimerization, which is essential for its structural stability and functional roles in ER quality control.

Calaxin is essential for the transmission of Ca2+-dependent asymmetric waves in sperm flagella

The paper investigates the role of calaxin in Ca2+-dependent asymmetric wave transmission in sperm flagella using ascidian sperm.

Cryo-EM structures of SERCA2b reveal the mechanism of regulation by the luminal extension tail

Cryo-EM structures of SERCA2b reveal how the luminal extension tail regulates its activity by controlling conformational transitions between states.

Biochemical characterizations of ER-resident peroxidases, GPx7 and GPx8, reveal their distinct and regulated oxidative activities

This study characterizes GPx7 and GPx8, showing GPx7 efficiently oxidizes PDI via H2O2, while GPx8's role in PDI oxidation is less central.

An integrated approach unravels a crucial structural property for the function of the insect steroidogenic Halloween protein Noppera-bo

This paper determines the structure of the insect steroidogenic Halloween protein Noppera-bo and identifies a conserved residue critical for its function.