M. Okumura

Client recognition differences between PDI and ERp46 to guide oxidative folding

The paper compares how PDI and ERp46 recognize client proteins during oxidative folding, showing distinct mechanisms that influence disulfide bond formation and protein quality control.

How to control unpredictable others in court-net sports

The paper examines strategies in court net sports to control unpredictable behavior, finding skilled players use regularity to disrupt expectations and promote cooperation.

Zinc finger domains bind low-complexity domain polymers

This study shows zinc finger domains bind low-complexity domain polymers in a cross-β-dependent manner, suppressing polymer formation and preferentially recognizing polymeric LC domains.

Dose-response relationship for the resistance of human insulin to degradation by insulin-degrading enzyme

The paper investigates how human insulin resistance to degradation by IDE varies with dose and identifies structural features of the insulin hexamer that influence degradation kinetics without zinc.

Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma

This study identifies neuromuscular gene expression in thymoma-associated myasthenia gravis by analyzing bulk and single-cell RNA-seq data, linking it to specific thymic epithelial cell subpopulations.

Distinct roles and actions of PDI family enzymes in catalysis of nascent-chain disulfide formation

This study compares the efficiency of PDI and ERp46 in catalyzing disulfide bond formation in nascent chains during translation, showing ERp46 is more effective early on.

A unique adhesive motif of protein disulfide isomerase P5 supports its function via dimerization

This study identifies a unique adhesive motif in P5 that enables dimerization, which is essential for its structural stability and functional roles in ER quality control.

Recapitulation of HIV-1 Env-Antibody Coevolution in Macaques Leading to Neutralization Breadth

Virus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.

Ran-GTP is non-essential to activate NuMA for spindle pole focusing, but dynamically polarizes HURP to control mitotic spindle length

This study shows that Ran-GTP is not essential for NuMA activation in spindle pole focusing but is required for HURP polarization and spindle length regulation during prometaphase.

Biochemical characterizations of ER-resident peroxidases, GPx7 and GPx8, reveal their distinct and regulated oxidative activities

This study characterizes GPx7 and GPx8, showing GPx7 efficiently oxidizes PDI via H2O2, while GPx8's role in PDI oxidation is less central.

Manumycin Polyketides Act as Molecular Glues Between UBR7 and P53 to Impair Breast Cancer Pathogenicity

The paper identifies manumycin polyketides as molecular glues that bind UBR7 and P53, impairing breast cancer pathogenicity through p53 activation and cell death.

Optogenetic reconstitution reveals that Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble

This study uses optogenetic reconstitution to show that NuMA clusters Dynein-Dynactin to generate cortical spindle-pulling forces through multi-arm interactions.