Structural basis for control of antibiotic production by bacterial hormones
S. Zhou, H. Bhukya, N. Malet, P. J. Harrison, D. Rea, M. J. Belousoff, H. Venugopal, P. K. Sydor, K. M. Styles, L. Song, M. J. Cryle, L. M. Alkhalaf, V. Fülöp, G. L. Challis, C. Corre
This study determines the structural basis for hormone-controlled antibiotic production in Actinobacteria by solving the X-ray structure of an MmfR-AHFCA complex and elucidating DNA release mechanisms.
bioRxiv · May 2, 2020Biochemistry