G. M. Cook

Establishment of an Inhalation Administration Noninvasive Murine Model for Rapidly Testing Drug Activity against Mycobacterium tuberculosis

This paper develops a non-invasive murine inhalation model using autoluminescent M. tuberculosis to rapidly assess drug efficacy against tuberculosis.

Extended blood stage sensitivity profiles of Plasmodium vivax to doxycycline and tafenoquine using Plasmodium cynomolgi as a model

The paper uses Plasmodium cynomolgi to determine the delayed antimalarial effects of doxycycline and tafenoquine on P. vivax, finding IC50 values for doxycycline and tafenoquine.

A marine sponge-associated mycobacterium closely related to Mycobacterium tuberculosis

This paper describes the discovery of a marine sponge-associated mycobacterium closely related to M. tuberculosis, which shares virulence factors but lacks virulence in mice.

KatG inactivation generates vulnerabilities in isoniazid resistant strains of Mycobacterium tuberculosis

The paper identifies vulnerabilities in isoniazid-resistant Mycobacterium tuberculosis strains by analyzing metabolic and transcriptional changes in katG mutants.

Zika viruses encode multiple upstream open reading frames in the 5' viral region with a role in neurotropism

This study identifies multiple upstream open reading frames (uORFs) in Zika virus (ZIKV) that influence neurotropism but not mosquito transmission.

The two-component system CroRS regulates isoprenoid flux to mediate antimicrobial tolerance in the bacterial pathogen Enterococcus faecalis

This paper identifies the CroRS two-component system as a regulator of isoprenoid biosynthesis in Enterococcus faecalis, linking it to antimicrobial tolerance through cell envelope maintenance.

Energy extraction from air: structural basis of atmospheric hydrogen oxidation

This paper determines the structure of a mycobacterial hydrogenase and explains how it selectively oxidizes atmospheric H2 while avoiding O2, enabling energy extraction from air.

Rate-limiting transport of positive charges through the Sec-machinery is integral to the mechanism of protein transport

The paper investigates protein transport through the Sec-machinery, finding that arginine diffusion limits transport and PMF contributes via a proton ratchet mechanism.

Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression

This study uses ribosome profiling to analyze PRRSV gene expression and reveals temporally regulated frameshifting and novel transcripts.

RNase HI depletion strongly potentiates cell killing by rifampicin in mycobacteria

This paper shows that reducing RNase HI activity in mycobacteria increases sensitivity to rifampicin, suggesting RNase HI as a target for new antibiotics.

Impaired succinate oxidation prevents growth and influences drug susceptibility in Mycobacterium tuberculosis

This study shows that impaired succinate oxidation in M. tuberculosis prevents growth and affects drug susceptibility by altering respiratory chain activity and drug responses.

Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine and Linezolid in a Murine Model of Tuberculosis.

This study evaluates novel oral tuberculosis regimens containing TB47, clofazimine, and linezolid, showing fast-acting sterilizing activity and no relapse in a mouse model.

Manipulation of the unfolded protein response: a pharmacological strategy against coronavirus infection

This paper investigates the unfolded protein response (UPR) in coronavirus infection and shows that pharmacological inhibition of the UPR significantly reduces viral replication.

Cellular and structural basis of synthesis of the unique intermediate dehydro-F420-0 in mycobacteria

This study resolves the biosynthesis pathway of F420 in mycobacteria by showing phosphoenolpyruvate, not 2-phospholactate, is the precursor and identifies the structural mechanism of dehydro-F420-0 production.

Two uptake hydrogenases differentially interact with the aerobic respiratory chain during mycobacterial growth and persistence

This study identifies two hydrogenases in Mycobacterium smegmatis that differentially interact with the respiratory chain during growth and persistence, performing distinct roles under varying conditions.

Dispersal of Mycobacterium tuberculosis to indigenous populations driven by historical European trade in the South Pacific

This paper traces the dispersal of Mycobacterium tuberculosis lineage 4.4 strains in New Zealand and Canada using genomic data, linking their spread to historical European trade and migration.

Alternative hydrogen uptake pathways suppress methane production in ruminants

This study identifies alternative hydrogen uptake pathways in ruminants that reduce methane production by competing with methanogens for hydrogen.