Author

P. J. Harrison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Cell Biology· 1 Developmental Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Assay:structural biology· 2

Frequent Co-Authors

A. Baldwin· 1 shared A. Giliberti· 1 shared A. Hellander· 1 shared A. Khan· 1 shared A. Lakshminarayanan· 1 shared A. Le Bas· 1 shared A. M. Giltrap· 1 shared A. M. J. J. Bonvin· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperBiophysics

A. Baldwin

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Developmentally-regulated splice remodeling shapes functional CACNA1C channel diversity during human neurodevelopment

M. Celik, O. A. Arshad, N. A. L. Hall, S. S. Yasarbas, M. Nikpour, L. Jonsson, C. M. Sellgren, M. Landen, A. Pantazis, P. J. Harrison, A. W. Mould, Erik Smedler

This study identifies developmentally-regulated alternative splicing of CACNA1C during human neurodevelopment and shows it affects CaV1.2 channel function.

bioRxiv · Nov 9, 2026 · PreprintDevelopmental Biology

EMinsight: a tool to capture cryoEM microscope configuration and experimental outcomes for analysis and deposition.

D. Hatton, J. Cha, S. Riggs, P. J. Harrison, J. Thiyagalingam, D. K. Clare, K. L. Morris

EMinsight captures and analyzes metadata from cryoEM single particle analysis experiments to improve instrument performance and data archiving.

bioRxiv · Feb 12, 2024Biophysics

Data Driven Taxonomy for Antipsychotic Medication: A New Classification System

R. A. McCutcheon, P. J. Harrison, O. D. Howes, P. K. McGuire, D. Taylor, T. Pillinger

This paper develops a data-driven classification system for antipsychotics based on receptor affinity and side effect prediction using clustering and machine learning.

bioRxiv · Jan 23, 2023Pharmacology & Toxicology

Cryptic pathogen-sugar interactions revealed by universal saturation transfer analysis

C. J. Buchanan, B. Gaunt, P. J. Harrison, Y. Yang, J. Liu, A. Khan, A. M. Giltrap, A. Le Bas, P. N. Ward, K. Gupta, M. Dumoux, S. Daga, N. Picchiotti, M. Baldassarri, E. Benetti, , B. G. Davis

This paper introduces uSTA, an NMR method to analyze protein-ligand interactions, revealing SARS-CoV-2 spike binds sialoside sugars via the NTD and showing variants-of-concern lose this binding.

bioRxiv · Apr 14, 2021Biophysics

Structural basis for control of antibiotic production by bacterial hormones

S. Zhou, H. Bhukya, N. Malet, P. J. Harrison, D. Rea, M. J. Belousoff, H. Venugopal, P. K. Sydor, K. M. Styles, L. Song, M. J. Cryle, L. M. Alkhalaf, V. Fülöp, G. L. Challis, C. Corre

This study determines the structural basis for hormone-controlled antibiotic production in Actinobacteria by solving the X-ray structure of an MmfR-AHFCA complex and elucidating DNA release mechanisms.

bioRxiv · May 2, 2020Biochemistry

Deep learning models for lipid-nanoparticle-based drug delivery

P. J. Harrison, H. Wieslander, A. Sabirsh, J. Karlsson, V. Malmsjö, A. Hellander, C. Wählby, O. Spjuth

The paper uses deep learning models to predict GFP expression in HepG2 cells exposed to lipid-nanoparticle-based mRNA therapeutics, showing improved performance with temporal dynamics modeling.

bioRxiv · Apr 6, 2020Cell Biology