Author

C. A. Whittaker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Cell Biology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 3 Organism:human· 3 Organism:yeast· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

J. C. Love· 3 shared A. Amon· 2 shared A. M. Biedermann· 2 shared A. Sandikci· 2 shared A. Terhorst· 2 shared L. E. Crowell· 2 shared M. K. Tracey· 2 shared N. C. Dalvie· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBioengineering

J. C. Love

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Phenotypic screens identify biologic regulators of nanoparticle uptake in diffuse midline glioma

E. L. Cheng, S. Pal, J. W. Tsai, C. B. Yampanis, S. Rangaswamy, J. Kenny-Serrano, M. Coppola, M. Ozdemir, K. Y. Cai, E. VanGosen, E. Bateman, K. R. Bennett, M. M. Billingsley, C. A. Whittaker, Y. Zhang, , J. P. Straehla

The paper identifies biologic regulators of nanoparticle uptake in diffuse midline glioma using CRISPR screens and functional assays, finding CTNNB1 and pathway members as key modulators.

bioRxiv · Sep 11, 2026 · PreprintBioengineering

A generative reference grammar of healthy TCR repertoires reveals cancer-associated immune remodeling

A. Balan, Y. Elhanati, K. E. Meza Landeros, M. De Almeida Mendes, J. Lai, S. S. A. Zaidi, M. Unal, B. Y. S. Kim, C.-H. G. Lucas, E. Runco, V. K. Puduvalli, J. Gantchev, C. A. Whittaker, P. Sharma, V. Tabar, , R. Karchin

CRAFT, a transformer model, learns a generative grammar of healthy TCR repertoires to detect cancer-associated immune remodeling through structured deviations in sequence space.

bioRxiv · Jun 20, 2026 · PreprintCancer Biology

Eradication of tumors with pre-existing antigenic heterogeneity by vaccine-mediated co-engagement of CAR T and endogenous T-cells

L. Ma, D. M. Morgan, I. Sulkaj, P. Yousefpour, C. A. Whittaker, W. Abraham, N. Li, J. C. Love, D. J. Irvine

This study shows vaccine boosting of CAR T-cells enhances tumor eradication by promoting antigen spreading and endogenous T-cell engagement, even in antigen-negative tumors.

bioRxiv · Oct 5, 2022 · PreprintImmunology

The environmental stress response regulates ribosome content in cell cycle-arrested S. cerevisiae

A. Terhorst, A. Sandikci, G. E. Neurohr, C. A. Whittaker, T. Szoradi, L. J. Holt, A. Amon

This study shows that cell cycle arrest in S. cerevisiae triggers ribosome downregulation via the Environmental Stress Response (ESR), linking cell cycle progression to biomass accumulation.

bioRxiv · May 14, 2021Cell Biology

Scalable, methanol-free manufacturing of the SARS-CoV-2 receptor binding domain in engineered Komagataella phaffii

N. C. Dalvie, A. M. Biedermann, S. A. Rodriguez-Aponte, C. A. Naranjo, H. D. Rao, M. P. Rajurkar, R. R. Lothe, U. S. Shaligram, R. S. Johnston, L. E. Crowell, S. Castelino, M. K. Tracey, C. A. Whittaker, J. C. Love

This paper describes an engineered Komagataella phaffii strain for methanol-free production of SARS-CoV-2 RBD, achieving a 5x increase in secreted titer and enabling scalable manufacturing for vaccine development.

bioRxiv · Apr 15, 2021Bioengineering

Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus

N. C. Dalvie, J. R. Brady, L. E. Crowell, M. K. Tracey, A. M. Biedermann, K. Kaur, J. M. Hickey, D. L. Kristensen, A. Bonnyman, S. A. Rodriguez-Aponte, C. A. Whittaker, M. Bok, C. Vega, T. Mukhopadhyay, S. B. Joshi, , J. C. Love

The paper engineers subunit antigens to improve vaccine manufacturing by reducing variants and enabling single-process production of a trivalent rotavirus vaccine.

bioRxiv · Nov 20, 2020Bioengineering

The environmental stress response causes ribosome loss in aneuploid yeast cells.

A. Terhorst, A. Sandikci, A. Keller, C. A. Whittaker, M. J. Dunham, A. Amon

This study clarifies that aneuploid yeast cells exhibit the environmental stress response (ESR) rather than the CAGE signature, leading to ribosome loss and reduced cellular density.

bioRxiv · Mar 25, 2020Cell Biology