Author

M. J. Lehane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Ecology· 2 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Research Focus:ecology & biodiversity· 2 Approach:microscopy & imaging analysis· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Acosta-Serrano· 3 shared C. Rose· 3 shared A. Casas-Sanchez· 2 shared A. Hope· 2 shared I. Tirados· 2 shared M. C. Stanton· 2 shared R. Selby· 2 shared S. J. Torr· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

A. Acosta-Serrano

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Author profile →

5 papers

Recent·Most cited

Impact of a national tsetse control programme to eliminate Gambian sleeping sickness in Uganda: a spatio-temporal modelling study.

J. Longbottom, J. Esterhuizen, A. Hope, M. J. Lehane, C. T. Mangwiro, A. Mugenyi, S. Dunkley, R. Selby, I. Tirados, S. J. Torr, M. C. Stanton

This study evaluates the impact of a national tsetse control program using Tiny Targets in Uganda, showing reduced tsetse abundance and low population levels across 4000 km2.

bioRxiv · Feb 16, 2024 · PreprintEcology

Tsetse salivary glycoproteins are modified with paucimannosidic N-glycans, are recognised by C-type lectins and bind to trypanosomes

R. P. Kozak, K. Mondragon-Shem, C. Williams, C. Rose, S. Perally, G. Caljon, J. van den abbeele, K. Wongtrakul-Kish, R. Gardner, D. Spencer, M. J. Lehane, A. Acosta-Serrano

The paper characterizes the N-glycan profile of tsetse salivary glycoproteins and shows they bind trypanosomes and are recognized by C-type lectins.

bioRxiv · Jun 25, 2020Biochemistry

Impact of Tiny Targets on Glossina fuscipes quanzensis, the primary vector of Human African Trypanosomiasis in the Democratic Republic of Congo.

I. Tirados, A. Hope, R. Selby, F. Mpembele, E. M. Miaka, M. Boelaert, M. J. Lehane, S. J. Torr, M. C. Stanton

This study evaluates the impact of Tiny Targets on tsetse fly populations in the Democratic Republic of Congo, finding an 85% reduction in fly catches following intervention.

bioRxiv · Apr 7, 2020Ecology

Trypanosoma brucei colonises the tsetse gut via an immature peritrophic matrix in the proventriculus

C. Rose, N. A. Dyer, A. Casas-Sanchez, A. J. Beckett, C. Solorzano, B. Middlehurst, M. Marcello, M. J. Lehane, I. A. Prior, A. Acosta-Serrano

This study shows Trypanosoma brucei colonizes the tsetse gut via the immature peritrophic matrix in the proventriculus, not directly through the midgut PM.

bioRxiv · Jan 7, 2019Microbiology

The crystal structure and localization of Trypanosoma brucei invariant surface glycoproteins suggest a more permissive VSG coat in the tsetse-transmitted metacyclic stage

A. Casas-Sanchez, S. Perally, R. Ramaswamy, L. R. Haines, C. Rose, C. Yunta, M. Aguilera-Flores, M. J. Lehane, I. C. Almeida, M. J. Boulanger, A. Acosta-Serrano

The paper identifies and characterizes a novel family of invariant surface proteins in the metacyclic stage of Trypanosoma brucei, suggesting a more permissive VSG coat structure that may aid vaccine development.

bioRxiv · Nov 26, 2018 · PreprintMicrobiology