Author

A. Casas-Sanchez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Assay:proteomics· 2 Organism:Arabidopsis· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

A. Acosta-Serrano· 5 shared C. Rose· 3 shared G. L. Hughes· 3 shared A. Romero-Ramirez· 2 shared E. I. Patterson· 2 shared I. C. Almeida· 2 shared M. J. Lehane· 2 shared A. J. Beckett· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersMicrobiology

A. Acosta-Serrano

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Vivaxin genes encode highly immunogenic non-variant antigens unique to the Trypanosoma vivax cell-surface

A. Romero-Ramirez, A. Casas-Sanchez, D. Autheman, C. W. Duffy, M. M. G. Teixeira, R. Z. Machado, J. Coombes, R. J. Flynn, G. J. Wright, A. P. Jackson

The paper identifies a new gene family in Trypanosoma vivax, called vivaxin, which encodes immunogenic surface proteins with potential as vaccine candidates.

bioRxiv · Feb 16, 2022 · PreprintMicrobiology

Protein N-glycosylation is essential for SARS-CoV-2 infection

A. Casas-Sanchez, A. Romero-Ramirez, E. Hargreaves, C. C. Ellis, B. I. Grajeda, I. Estevao, E. I. Patterson, G. L. Hughes, I. C. Almeida, T. Zech, A. Acosta-Serrano

This study shows that host and viral N-glycosylation are essential for SARS-CoV-2 infection, with inhibition reducing infectivity and virion production.

bioRxiv · Feb 5, 2021 · PreprintMicrobiology

Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis

A. Acosta-Serrano, M. Sterkel, L. Haines, A. Casas-Sanchez, V. Owino, R. Vionette-Amaral, S. Quek, C. Rose, M. Silva dos Santos, N. Garcia Escude, H. Ismail, M. I. Paine, S. M. Barribeau, S. Wagstaff, J. I. MacRae, , P. L. Oliveira

This study shows that nitisinone can kill tsetse flies without harming bees, offering an eco-friendly method to control African trypanosomiasis transmission.

bioRxiv · Jun 8, 2020Biochemistry

Methods of inactivation of SARS-CoV-2 for downstream biological assays

E. I. Patterson, T. Prince, E. R. Anderson, A. Casas-Sanchez, S. L. Smith, C. Cansado-Utrilla, L. Turtle, G. L. Hughes

This study tests methods to inactivate SARS-CoV-2 for use in lower containment laboratories, finding that heat, detergents, and UV light effectively inactivate the virus.

bioRxiv · May 21, 2020Microbiology

Gut-associated bacteria invade the midgut epithelium of Aedes aegypti and stimulate innate immunity and suppress Zika virus infection in cells.

S. Hegde, D. Voronin, A. Casas-Sanchez, M. A. Saldana, E. Heinz, A. Acosta-Serrano, V. L. Popov, A. K. Chopra, G. L. Hughes

This study shows gut bacteria invade mosquito cells, activate immune pathways, and reduce Zika virus infection.

bioRxiv · Jan 16, 2020 · PreprintMicrobiology

Trypanosoma brucei colonises the tsetse gut via an immature peritrophic matrix in the proventriculus

C. Rose, N. A. Dyer, A. Casas-Sanchez, A. J. Beckett, C. Solorzano, B. Middlehurst, M. Marcello, M. J. Lehane, I. A. Prior, A. Acosta-Serrano

This study shows Trypanosoma brucei colonizes the tsetse gut via the immature peritrophic matrix in the proventriculus, not directly through the midgut PM.

bioRxiv · Jan 7, 2019Microbiology

The crystal structure and localization of Trypanosoma brucei invariant surface glycoproteins suggest a more permissive VSG coat in the tsetse-transmitted metacyclic stage

A. Casas-Sanchez, S. Perally, R. Ramaswamy, L. R. Haines, C. Rose, C. Yunta, M. Aguilera-Flores, M. J. Lehane, I. C. Almeida, M. J. Boulanger, A. Acosta-Serrano

The paper identifies and characterizes a novel family of invariant surface proteins in the metacyclic stage of Trypanosoma brucei, suggesting a more permissive VSG coat structure that may aid vaccine development.

bioRxiv · Nov 26, 2018 · PreprintMicrobiology