PGC-1α overexpression partially rescues impaired oxidative and contractile pathophysiology following volumetric muscle loss injury
W. M. Southern, A. S. Nichenko, K. F. Tehrani, M. J. McGranahan, L. Krishnan, A. E. Qualls, N. J. Jenkins, L. J. Mortensen, H. Yin, A. Yin, R. E. Guldberg, S. M. Greising, J. A. Call
This study shows that PGC-1α overexpression improves oxidative capacity and muscle strength in VML-injured muscle, suggesting it as a potential therapeutic target.
bioRxiv · Jan 31, 2019Physiology