Author

R. E. Guldberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 8 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:development & morphogenesis· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Organism:rat· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. E. Vantucci· 3 shared L. B. Wood· 3 shared L. E. Bertassoni· 3 shared L. Krishnan· 3 shared M. A. Ruehle· 3 shared N. J. Willett· 3 shared R. Subbiah· 3 shared A. Athirasala· 2 shared

Activity by Year

2018-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBioengineering

C. E. Vantucci

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

In vitro development and optimization of cell-laden injectable bioprinted gelatin methacryloyl (GelMA) microgels mineralized on the nanoscale

M. G. C. Sousa, G. d. S. Balbinot, R. Subbiah, R. Visalakshan, A. Tahayeri, M. E. Q. L. Verde, A. Athirasala, G. Romanowicz, R. E. Guldberg, L. E. Bertassoni

This study develops and optimizes injectable bioprinted GelMA microgels that can be mineralized at the nanoscale to enhance osteocyte maturation and mimic bone microarchitecture.

bioRxiv · Oct 10, 2023 · PreprintBioengineering

Effects of osteogenic ambulatory mechanical stimulation on early stages of BMP-2mediated bone repair

B. S. Klosterhoff, C. E. Vantucci, J. Kaiser, K. G. Ong, L. B. Wood, J. A. Weiss, R. E. Guldberg, N. J. Willett

This study investigates how mechanical loading affects early bone repair stages in a rat model, showing changes in cytokine expression, angiogenesis, and endochondral ossification.

bioRxiv · Jul 28, 2020Bioengineering

Effects of Controlled Dual Growth Factor Delivery on Bone Regeneration Following Composite Bone-Muscle Injury

R. Subbiah, A. Cheng, M. A. Ruehle, M. H. Hettiaratchi, L. E. Bertassoni, R. E. Guldberg

This study evaluates a smart delivery system for dual growth factor (BMP-2 and VEGF) release in composite bone-muscle injuries, finding no synergistic effect but improved bone healing with low-dose delivery.

bioRxiv · Mar 25, 2020Bioengineering

3D printing of Microgel-loaded Modular LEGO-like Cages as Instructive Scaffolds for Tissue Engineering

C. Hipfinger, R. Subbiah, A. Tahayeri, A. Athirasala, S. Horsophonphong, G. Thrivikraman, C. M. Franca, D. A. Cunha, A. Mansoorifar, A. Zahariev, J. M. Jones, P. G. Coelho, L. Witek, H. Xie, R. E. Guldberg, L. E. Bertassoni

This paper introduces a 3D-printed modular LEGO-like cage scaffold system for tissue engineering that allows scalable assembly and controlled therapeutic loading.

bioRxiv · Mar 2, 2020 · PreprintBioengineering

Mechanical Regulation of Microvascular Angiogenesis

M. A. Ruehle, E. A. Eastburn, S. A. LaBelle, L. Krishnan, J. A. Weiss, J. D. Boerckel, L. B. Wood, R. E. Guldberg, N. J. Willett

This study investigates how mechanical strain on the extracellular matrix affects microvascular angiogenesis, finding that timing and magnitude of compression significantly influence vessel growth and signaling pathways.

bioRxiv · Jan 14, 2020 · PreprintBioengineering

Development of Systemic Immune Dysregulation in a Rat Trauma Model with Biomaterial-Associated Infection

C. E. Vantucci, H. Ahn, M. L. Schenker, P. Pradhan, L. B. Wood, R. E. Guldberg, K. Roy, N. Willett

This study investigates the systemic immune response to orthopedic biomaterial-associated infection in rats, finding long-term immune dysregulation and altered cytokine responses.

bioRxiv · Jan 10, 2020Bioengineering

Real-time monitoring of mechanical cues in the regenerative niche reveal dynamic strain magnitudes that enhance bone repair

B. S. Klosterhoff, J. Kaiser, B. Nelson, S. S. Karipott, M. A. Ruehle, S. J. Hollister, J. Weiss, K. G. Ong, N. Willett, R. E. Guldberg

This study uses an implantable strain sensor to monitor mechanical cues during bone repair in rats, showing that dynamic strain magnitudes correlate with healing status.

bioRxiv · Jun 6, 2019 · PreprintBioengineering

PGC-1α overexpression partially rescues impaired oxidative and contractile pathophysiology following volumetric muscle loss injury

W. M. Southern, A. S. Nichenko, K. F. Tehrani, M. J. McGranahan, L. Krishnan, A. E. Qualls, N. J. Jenkins, L. J. Mortensen, H. Yin, A. Yin, R. E. Guldberg, S. M. Greising, J. A. Call

This study shows that PGC-1α overexpression improves oxidative capacity and muscle strength in VML-injured muscle, suggesting it as a potential therapeutic target.

bioRxiv · Jan 31, 2019Physiology

Effects of BMP-2 dose and delivery of microvascular fragments on healing of bone defects with concomitant volumetric muscle loss

M. Ruehle, L. Krishnan, C. E. Vantucci, Y. Wang, H. Y. Stevens, K. Roy, R. E. Guldberg, N. J. Willett

This study tests the effect of BMP-2 dose and co-delivery of microvascular fragments on healing of bone defects with muscle loss, finding dose-dependent bone regeneration without heterotopic ossification.

bioRxiv · Sep 27, 2018Bioengineering