Cryo-EM studies of the four E. coli paralogs establish ABCF proteins as master plumbers of the peptidyl-transferase center of the ribosome
S. Singh, R. C. Gentry, Z. Fu, N. A. Bailey, C. G. Altomare, K.-H. Wong, M. J. Neky, C. Wang, K. K. Ray, Y.-C. Chi, Z. Zhang, R. A. Grassucci, J. Frank, G. Boël, R. L. Gonzalez, J. F. Hunt
This study presents cryo-EM structures of four E. coli ABCF paralogs bound to the ribosome, revealing their role in modulating tRNA geometry and catalytic function at the peptidyl-transferase center.
bioRxiv · Jun 15, 2023 · PreprintBiophysics