Author

G. Boël

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 3 Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

J. F. Hunt· 3 shared K.-H. Wong· 2 shared M. J. Neky· 2 shared N. A. Bailey· 2 shared R. L. Gonzalez· 2 shared S. Singh· 2 shared A. Liponska· 1 shared C. Bouchachi· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMicrobiology

J. F. Hunt

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3 papers

Recent·Most cited

Base composition at the start of the coding sequence controls the balance between translation initiation and mRNA degradation in E. coli .

A. Liponska, L. Monlezun, I. Wilkins, S. Ngo, T. Oïffer, C. Bouchachi, J. F. Hunt, D. P. Aalberts, G. Boël

The paper shows that A-rich first six codons in E. coli mRNAs enhance translation initiation and stability, leading to higher protein expression.

bioRxiv · Mar 21, 2024Microbiology

Cryo-EM studies of the four E. coli paralogs establish ABCF proteins as master plumbers of the peptidyl-transferase center of the ribosome

S. Singh, R. C. Gentry, Z. Fu, N. A. Bailey, C. G. Altomare, K.-H. Wong, M. J. Neky, C. Wang, K. K. Ray, Y.-C. Chi, Z. Zhang, R. A. Grassucci, J. Frank, G. Boël, R. L. Gonzalez, J. F. Hunt

This study presents cryo-EM structures of four E. coli ABCF paralogs bound to the ribosome, revealing their role in modulating tRNA geometry and catalytic function at the peptidyl-transferase center.

bioRxiv · Jun 15, 2023 · PreprintBiophysics

Comparative genetic, biochemical, and biophysical analyses of the four E. coli ABCF paralogs support distinct functions related to mRNA translation

F. Ousalem, S. Singh, N. A. Bailey, K.-H. Wong, L. Zhu, M. J. Neky, C. Sibindi, J. Fei, R. L. Gonzalez, G. Boël, J. F. Hunt

The paper compares four E. coli ABCF paralogs to determine their distinct roles in mRNA translation using biochemical and biophysical assays.

bioRxiv · Jun 11, 2023 · PreprintBiochemistry