Author

R. A. Grassucci

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 3 Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Research Focus:synaptic & neural circuits· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

J. Frank· 3 shared Z. Fu· 3 shared C. Wang· 2 shared J. F. Hunt· 2 shared K.-H. Wong· 2 shared S. Singh· 2 shared A. Mezzell· 1 shared B. Chen· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiophysics

J. Frank

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3 papers

Recent·Most cited

Cryo-EM studies of the four E. coli paralogs establish ABCF proteins as master plumbers of the peptidyl-transferase center of the ribosome

S. Singh, R. C. Gentry, Z. Fu, N. A. Bailey, C. G. Altomare, K.-H. Wong, M. J. Neky, C. Wang, K. K. Ray, Y.-C. Chi, Z. Zhang, R. A. Grassucci, J. Frank, G. Boël, R. L. Gonzalez, J. F. Hunt

This study presents cryo-EM structures of four E. coli ABCF paralogs bound to the ribosome, revealing their role in modulating tRNA geometry and catalytic function at the peptidyl-transferase center.

bioRxiv · Jun 15, 2023 · PreprintBiophysics

Mechanism of dual pharmacological correction and potentiation of human CFTR

C. Wang, Z. Yang, B. J. Loughlin, H. Xu, G. Veit, S. Vorobiev, O. B. Clarke, F. Jiang, Y. Li, S. Singh, Z. Rich, E. R. Menten, R. A. Grassucci, W. Wang, A. Mezzell, , J. F. Hunt

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

bioRxiv · Oct 10, 2022 · PreprintBiophysics

The structural basis for release factor activation during translation termination revealed by time-resolved cryogenic electron microscopy

Z. Fu, G. Indrisiunaite, S. Kaledhonkar, B. Shah, M. Sun, B. Chen, R. A. Grassucci, M. Ehrenberg, J. Frank

This paper uses time-resolved cryo-EM to directly observe the transition of bacterial release factors RF1 and RF2 from a compact to extended conformation during translation termination.

bioRxiv · Nov 14, 2018Biophysics