Author

M. J. O'Melia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

H. Zhou· 3 shared P.-J. Lei· 3 shared T. P. Padera· 3 shared A. S. Kumar· 2 shared D. Jones· 2 shared J. J. Rajotte· 2 shared J. M. Ubellacker· 2 shared J. W. Baish· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

H. Zhou

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Author profile →

4 papers

Recent·Most cited

Lymphatic muscle cells are unique cells that undergo aging induced changes

P.-J. Lei, K. J. Ruscic, K. Roh, J. J. Rajotte, M. J. O'Melia, E. M. Bouta, M. Marquez, E. R. Pereira, A. S. Kumar, G. Arroyo-Ataz, M. S. Razavi, H. Zhou, L. Menzel, H. Kumra, M. Duquette, , T. P. Padera

This study creates a single-cell transcriptomic atlas of lymphatic muscle cells in mice across ages, revealing age-related transcriptional changes and a pro-inflammatory environment in aged cells.

bioRxiv · Nov 18, 2023Cell Biology

Distant lymph nodes compensate for resected tumor-draining lymph nodes during cancer immunotherapy

L. Menzel, H. Zhou, J. W. Baish, M. J. O'Melia, L. B. Darragh, E. Specht, D. N. Effiom, J. Czapla, P.-j. Lei, J. J. Rajotte, L. Liu, M. R. Nikmaneshi, M. S. Razavi, M. G. Vander Heiden, J. M. Ubellacker, , T. P. Padera

The paper shows that removing tumor-draining lymph nodes does not impair immune checkpoint blockade response, as distant lymph nodes compensate for the loss.

bioRxiv · Sep 19, 2023Cancer Biology

Breast cancer progression and metastasis to lymph nodes reveals cancer cell plasticity and MHC class II-mediated immune regulation

P.-J. Lei, E. Pereira, P. Andersson, Z. Amoozgar, J. W. V. Wijnbergen, M. J. O'Melia, H. Zhou, S. Chatterjee, W. W. Ho, J. M. Posada, A. S. Kumar, S. Morita, C. Chuang, I. Ergin, D. Jones, , T. P. Padera

This study identifies MHC class II expression in metastatic breast cancer cells and shows its role in immune evasion and tumor progression through IFN-gamma and JAK/STAT signaling.

bioRxiv · Oct 30, 2022Cancer Biology

Tumor microenvironments impair T cell receptor affinity and function

Z. Yuan, M. J. O'Melia, K. Li, J. Lyu, A. M. Rosado, V. E. Watson, A. H. K. Ashkezari, F. Zhou, V. Kansal, B. Kinney, S. Travaglino, L. O. Doudy, R. K. Noel, S. N. Lucas, S. L. Kong, , C. Zhu

This study shows that CD8+ T cells in the tumor microenvironment have reduced TCR-pMHC affinity and function, impairing their anti-tumor activity.

bioRxiv · Sep 11, 2022 · PreprintImmunology