Author

P.-J. Lei

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

P. Huang· 4 shared D. Jones· 3 shared H. Zhou· 3 shared L. L. Munn· 3 shared M. J. O'Melia· 3 shared T. P. Padera· 3 shared A. S. Kumar· 2 shared J. J. Rajotte· 2 shared

Activity by Year

2022-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

P. Huang

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Author profile →

5 papers

Recent·Most cited

Lymphatic muscle cells are unique cells that undergo aging induced changes

P.-J. Lei, K. J. Ruscic, K. Roh, J. J. Rajotte, M. J. O'Melia, E. M. Bouta, M. Marquez, E. R. Pereira, A. S. Kumar, G. Arroyo-Ataz, M. S. Razavi, H. Zhou, L. Menzel, H. Kumra, M. Duquette, , T. P. Padera

This study creates a single-cell transcriptomic atlas of lymphatic muscle cells in mice across ages, revealing age-related transcriptional changes and a pro-inflammatory environment in aged cells.

bioRxiv · Nov 18, 2023Cell Biology

Distant lymph nodes compensate for resected tumor-draining lymph nodes during cancer immunotherapy

L. Menzel, H. Zhou, J. W. Baish, M. J. O'Melia, L. B. Darragh, E. Specht, D. N. Effiom, J. Czapla, P.-j. Lei, J. J. Rajotte, L. Liu, M. R. Nikmaneshi, M. S. Razavi, M. G. Vander Heiden, J. M. Ubellacker, , T. P. Padera

The paper shows that removing tumor-draining lymph nodes does not impair immune checkpoint blockade response, as distant lymph nodes compensate for the loss.

bioRxiv · Sep 19, 2023Cancer Biology

Isolation and characterization of a novel hormone receptor positive mammary adenocarcinoma MCa-P1362 with stromal drivers of tumor growth, metastasis, and drug resistance

S. Jana, W. Li, P.-J. Lei, Z. Wang, P. Huang, D. Jones

The paper characterizes a novel hormone receptor positive mammary adenocarcinoma model, MCa-P1362, showing stromal-cell interactions drive tumor growth, metastasis, and drug resistance.

bioRxiv · Jun 2, 2023 · PreprintCancer Biology

Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy

J. Chen, Z. Amoozgar, X. LIU, S. Aoki, Z. Liu, S. Shin, A. Matsui, Z. Pu, P.-J. Lei, M. Datta, L. Zhu, Z. Ruan, L. Shi, D. Staiculescu, K. Inoue, , D. G. Duda

This paper shows that combining chemotherapy with CTLA-4 blockade reprograms the immune microenvironment of intrahepatic cholangiocarcinoma, enhancing the effectiveness of anti-PD1 therapy.

bioRxiv · Jan 26, 2023Cancer Biology

Breast cancer progression and metastasis to lymph nodes reveals cancer cell plasticity and MHC class II-mediated immune regulation

P.-J. Lei, E. Pereira, P. Andersson, Z. Amoozgar, J. W. V. Wijnbergen, M. J. O'Melia, H. Zhou, S. Chatterjee, W. W. Ho, J. M. Posada, A. S. Kumar, S. Morita, C. Chuang, I. Ergin, D. Jones, , T. P. Padera

This study identifies MHC class II expression in metastatic breast cancer cells and shows its role in immune evasion and tumor progression through IFN-gamma and JAK/STAT signaling.

bioRxiv · Oct 30, 2022Cancer Biology