Author

M. J. Sarink

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. G. M. Tielens· 2 shared J. J. van Hellemond· 2 shared A. Verbon· 1 shared F. R. Opperdoes· 1 shared H. Wienk· 1 shared J. F. Brouwers· 1 shared J. F. De Jonckheere· 1 shared M. Bexkens· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersMicrobiology

A. G. M. Tielens

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2 papers

Recent·Most cited

Inhibition of fatty acid oxidation as a new target to treat Primary Amoebic Meningoencephalitis by repurposing two well-known drugs

M. J. Sarink, A. Verbon, A. G. M. Tielens, J. J. van Hellemond

This study identifies two existing drugs, thioridazine and valproic acid, that inhibit the growth of Naegleria gruberi, a close relative of the PAM-causing N. fowleri, suggesting their potential repurposing for PAM treatment.

bioRxiv · May 26, 2019 · PreprintMicrobiology

Lipids are the preferred substrate of the protist Naegleria gruberi, relative of a human brain pathogen

M. Bexkens, V. Zimorski, M. J. Sarink, H. Wienk, J. F. Brouwers, J. F. De Jonckheere, W. F. Martin, F. R. Opperdoes, J. J. van Hellemond, A. G. M. Tielens

This study shows that Naegleria gruberi relies on lipid oxidation for growth and energy metabolism, unlike glucose or amino acids, and suggests similar metabolism in its pathogenic relative N. fowleri.

bioRxiv · Jul 24, 2018Biochemistry