Author

A. G. M. Tielens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. J. van Hellemond· 3 shared J. F. Brouwers· 2 shared M. J. Sarink· 2 shared A. Verbon· 1 shared F. R. Opperdoes· 1 shared H. Wienk· 1 shared J. F. De Jonckheere· 1 shared M. Bexkens· 1 shared

Activity by Year

2018-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiochemistry

J. J. van Hellemond

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintMay 26, 2019

Inhibition of fatty acid oxidation as a new target to treat Primary Amoebic Meningoencephalitis by repurposing two well-known drugs

M. J. Sarink, A. Verbon, A. G. M. Tielens, J. J. van Hellemond

This study identifies two existing drugs, thioridazine and valproic acid, that inhibit the growth of Naegleria gruberi, a close relative of the PAM-causing N. fowleri, suggesting their potential repurposing for PAM treatment.

DOI 10.1101/650325

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistrybioRxivNov 6, 2018

Schistosoma mansoni does not and cannot oxidize fatty acids, but these are used for biosynthetic purposes instead

M. L. Bexkens, M. M. Mebius, M. Houweling…·J. J. van Hellemond

This study shows that Schistosoma mansoni does not oxidize fatty acids but uses them for biosynthesis, which is critical for egg production and miracidium development.

DOI 10.1016/j.ijpara.2019.03.005

humanstatistical model

𝕏 PostBluesky

BiochemistrybioRxivJul 24, 2018

Lipids are the preferred substrate of the protist Naegleria gruberi, relative of a human brain pathogen

M. Bexkens, V. Zimorski, M. J. Sarink…·A. G. M. Tielens

This study shows that Naegleria gruberi relies on lipid oxidation for growth and energy metabolism, unlike glucose or amino acids, and suggests similar metabolism in its pathogenic relative N. fowleri.

DOI 10.1016/j.celrep.2018.09.055

humanexperimental assay

𝕏 PostBluesky