Coordinated changes in glycosylation regulate the germinal centre through CD22
J. R. Enterina, S. Sarkar, L. Streith, J. Jung, B. M. Arlian, S. J. Meyer, H. Takematsu, C. Xiao, T. Baldwin, L. Nitschke, M. J. Shlomchick, J. C. Paulson, M. S. Macauley
This study shows that glycan remodeling and CD22 downregulation are essential for proper germinal center function, including plasma cell output and antibody affinity maturation.
bioRxiv · Apr 30, 2021 · PreprintImmunology