Phenotypic plasticity of ER+ breast cancer in the bone microenvironment
I. L. Bado, H. Wang, P. Sarkar, J. Liu, W. Wu, W. Zhang, H.-C. Lo, A. Muscallera, M. Janghorban, I.-S. Kim, S. Singh, A. Goldstein, P. Singh, H. Shixia, G. M. Waleed, , X. H. F. Zhang
The paper shows that the bone microenvironment induces endocrine resistance in ER+ breast cancer metastases through epigenomic reprogramming mediated by EZH2.
bioRxiv · Nov 14, 2020 · PreprintCancer Biology