A. Goldstein

YAP dysregulation triggers hypertrophy by CCN2 secretion and TGFβ uptake in human pluripotent stem cell-derived cardiomyocytes

This study shows that YAP overactivation in HCM mutant cardiomyocytes drives hypertrophy via CCN2 secretion and TGFβ uptake.

Microwell-Based Flow Culture Increases Viability and Restores Drug Response in Prostate Cancer Spheroids

This study introduces a Microwell Flow Device that improves spheroid viability and drug response in prostate cancer models by reducing hypoxia-related necrosis.

Utilizing multi-objective decision support tools for protected area selection

This paper presents a global decision support tool for selecting protected areas by balancing multiple conservation objectives and highlighting trade-offs among them.

An international report on bacterial communities in esophageal squamous cell carcinoma

This study identifies bacterial communities associated with esophageal squamous cell carcinoma (ESCC) tumors and finds similar enrichment of oral bacteria in both saliva and tumor microbiomes of ESCC patients.

Phenotypic plasticity of ER+ breast cancer in the bone microenvironment

The paper shows that the bone microenvironment induces endocrine resistance in ER+ breast cancer metastases through epigenomic reprogramming mediated by EZH2.

Highly multiplexed immune profiling throughout adulthood reveals kinetics of lymphocyte infiltration in the aging mouse prostate

This study reveals that T and B lymphocyte populations increase in the mouse prostate between 6 and 12 months of age, indicating age-related inflammation kinetics in the prostate.