Author

M. Jenkyn-Bedford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:structural biology· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

D. Baretic· 1 shared G. Cannone· 1 shared I. R. Short· 1 shared J. T. P. Yeeles· 1 shared L. Pellegrini· 1 shared M. L. Kilkenny· 1 shared M. Skehel· 1 shared N. J. Rzechorzek· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

D. Baretic

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2 papers

Recent·Most cited

Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork

D. Baretic, M. Jenkyn-Bedford, V. Aria, G. Cannone, M. Skehel, J. T. P. Yeeles

The paper presents cryo-EM structures of the replisome components CMG, Ctf4, Csm3/Tof1, and Mrc1 bound to a replication fork, revealing their interactions and mechanisms in DNA replication and fork stabilization.

bioRxiv · Dec 18, 2019Biochemistry

Structural basis for inhibition of human primase by arabinofuranosyl nucleoside analogues Fludarabine and Vidarabine

S. Holzer, N. J. Rzechorzek, I. R. Short, M. Jenkyn-Bedford, L. Pellegrini, M. L. Kilkenny

This study provides a structural basis for how Fludarabine and Vidarabine inhibit human primase, suggesting ways to improve their therapeutic efficacy and reduce toxicity.

bioRxiv · Apr 11, 2019Biochemistry