Author

L. Pellegrini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 3 Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:human· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Assay:cryo-EM· 3 Assay:structural biology· 3 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

N. J. Rzechorzek· 4 shared D. Y. Chirgadze· 3 shared M. L. Kilkenny· 3 shared D. Bollschweiler· 2 shared J. D. Maman· 2 shared S. W. Hardwick· 2 shared A. Arashiro Pulschen· 1 shared A. Beilina· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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4 shared papersBiophysics

N. J. Rzechorzek

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Author profile →

9 papers

Recent·Most cited

A metal ion-dependent mechanism of RAD51 nucleoprotein filament disassembly

R. Appleby, D. Bollschweiler, D. Y. Chirgadze, L. Joudeh, L. Pellegrini

This study identifies a metal ion-dependent mechanism for RAD51 nucleoprotein filament disassembly through cryoEM analysis of ATP and ADP-bound states.

bioRxiv · Feb 18, 2023Biochemistry

Structural basis for the interaction of SARS-CoV-2 virulence factor nsp1 with Pol α - Primase

M. L. Kilkenny, C. E. Veale, A. Guppy, S. W. Hardwick, D. Y. Chirgadze, N. J. Rzechorzek, J. D. Maman, L. Pellegrini

This study reports the cryoEM structure of the SARS-CoV-2 nsp1-primosome complex, revealing how nsp1 interacts with the DNA polymerase-primase complex to disrupt immune responses.

bioRxiv · Jun 17, 2021 · PreprintBiophysics

Structural basis for the coiled-coil architecture of human CtIP

C. R. Morton, N. J. Rzechorzek, J. D. Maman, M. Kuramochi, H. Sekiguchi, R. P. Rambo, Y. C. Sasaki, O. R. Davies, L. Pellegrini

This study presents an atomic model of human CtIP's structure, revealing its extended dimer-of-dimers architecture and dynamic zinc-binding motif involved in DNA repair.

bioRxiv · Mar 5, 2021Biophysics

Pathogenic mutations in LRRK2 sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia

A. Mamais, N. Landeck, R. G. Langston, L. Bonet-Ponce, N. Smith, A. Beilina, A. Kaganovich, M. C. Ghosh, L. Pellegrini, J. H. Kluss, R. Kumaran, I. Papazoglou, N. Maio, C. Kim, D. C. Gershlick, M. R. Cookson

This study shows that LRRK2 mutations sequester Rab8a into lysosomes and disrupt transferrin-mediated iron uptake in microglia, linking LRRK2 dysfunction to iron dysregulation in Parkinson's disease.

bioRxiv · Jul 27, 2020 · PreprintCell Biology

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

D. E. Scott, N. J. Francis-Newton, M. E. Marsh, A. G. Coyne, G. Fischer, T. Moschetti, A. R. Bayly, T. D. Sharpe, K. T. Haas, L. Barber, C. Valenzano, R. Srinivasan, D. J. Huggins, M. Ehebauer, A. Esposito, , C. Abell

The paper identifies CAM833, a small-molecule inhibitor of BRCA2-RAD51 interaction, which disrupts RAD51 assembly and enhances DNA damage-induced cell death in BRCA2-wildtype cells.

bioRxiv · Jul 15, 2020Cancer Biology

CryoEM structures of human CMG - ATPγS - DNA and CMG - AND-1 complexes

N. J. Rzechorzek, S. W. Hardwick, V. A. Jatikusumo, D. Y. Chirgadze, L. Pellegrini

The paper reports cryoEM structures of human CMG helicase bound to DNA and AND-1, revealing DNA binding interactions and replisome interactions.

bioRxiv · Jan 22, 2020Biochemistry

Proteasome-mediated protein degradation resets the cell division cycle and triggers ESCRT-III-mediated cytokinesis in an archaeon

G. Tarrason Risa, F. Hurtig, S. Bray, A. Hafner, L. Harker-Kirschneck, P. Faull, C. Davis, D. Papatziamou, D. R. Mutavchiev, C. Fan, L. Meneguello, A. Arashiro Pulschen, G. Dey, S. Culley, M. L. Kilkenny, , B. Baum

This study identifies proteasome-mediated degradation of CdvB as a mechanism resetting the cell division cycle and triggering cytokinesis in the archaeon Sulfolobus acidocaldarius.

bioRxiv · Sep 18, 2019 · PreprintCell Biology

Structural basis for inhibition of human primase by arabinofuranosyl nucleoside analogues Fludarabine and Vidarabine

S. Holzer, N. J. Rzechorzek, I. R. Short, M. Jenkyn-Bedford, L. Pellegrini, M. L. Kilkenny

This study provides a structural basis for how Fludarabine and Vidarabine inhibit human primase, suggesting ways to improve their therapeutic efficacy and reduce toxicity.

bioRxiv · Apr 11, 2019Biochemistry

Reconstitution of a flexible SYCP3-DNA fibre suggests a mechanism for SYCP3 coating of the meiotic chromosome axis

D. Bollschweiler, L. Radu, J. M. Plitzko, R. M. Henderson, I. Mela, L. Pellegrini

This study uses cryo-electron tomography and atomic force microscopy to show that SYCP3 forms a flexible fibre that binds DNA, suggesting a mechanism for coating the meiotic chromosome axis.

bioRxiv · Jul 14, 2018Biophysics