N. J. Rzechorzek

This study reports the cryoEM structure of the SARS-CoV-2 nsp1-primosome complex, revealing how nsp1 interacts with the DNA polymerase-primase complex to disrupt immune responses.

This study presents an atomic model of human CtIP's structure, revealing its extended dimer-of-dimers architecture and dynamic zinc-binding motif involved in DNA repair.

The paper reports cryoEM structures of human CMG helicase bound to DNA and AND-1, revealing DNA binding interactions and replisome interactions.

This study provides a structural basis for how Fludarabine and Vidarabine inhibit human primase, suggesting ways to improve their therapeutic efficacy and reduce toxicity.