T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy
A. S. Hansen, L. S. Jensen, K. G. Ryttersgaard, C. Krapp, J. Just, K. R. Gammelgaard, K. L. Jonsson, M. Johannsen, A. Etzerodt, B. W. Deleuran, M. R. Jakobsen
This study shows that T-cell derived extracellular vesicles enhance macrophage STING activation, improving cancer immunotherapy by reprogramming macrophages to a pro-inflammatory state.
bioRxiv · Jan 9, 2023Immunology