J. Just

Complementing Muscle Regeneration: Fibro-Adipogenic Progenitor and Macrophage-Mediated Repair of Elderly Human Skeletal Muscle

This study identifies fibro-adipogenic progenitors and macrophages as key players in elderly human skeletal muscle regeneration through spatial and single-cell transcriptomics, revealing their interplay via complement factor C3.

HSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis

This study investigates how HSP60 deficiency disrupts mitochondrial proteostasis and dysregulates cholesterol synthesis, leading to developmental abnormalities and hypomyelination.

Seasonally increasing parasite load is associated with microbiome dysbiosis in wild bumblebees

This study examines microbiome diversity in wild bumblebees and finds seasonal increases in parasite load linked to microbiome dysbiosis.

T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy

This study shows that T-cell derived extracellular vesicles enhance macrophage STING activation, improving cancer immunotherapy by reprogramming macrophages to a pro-inflammatory state.

Cell layer-specific expression of the homeotic MADS-box transcription factor PhDEF contributes to modular petunia petal morphogenesis

The paper shows that cell-layer specific expression of PhDEF affects different parts of petunia petals, revealing modular development.

Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetes patients

This study identifies CD90+ fibro-adipogenic progenitors in T2DM skeletal muscle and shows PDGF signaling drives their pathogenic behavior, which is mitigated by Metformin.

Transcriptomics at maize embryo/endosperm interfaces identify a novel transcriptionally distinct endosperm sub-domain adjacent to the embryo scutellum (EAS)

The paper identifies a novel endosperm sub-domain adjacent to the embryo scutellum in maize kernels through transcriptomic analysis of interface tissues.

The molecular signatures of compatible and incompatible pollination

The paper identifies molecular signatures of compatible and incompatible pollination in Arabidopsis thaliana by analyzing transcriptomic changes during pollen-stigma interaction.