Author

M. K. Brewer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

A. DePaoli-Roach· 1 shared A. Gruart· 1 shared A. Hervera· 1 shared A. Kuchtova· 1 shared A. Uittenbogaard· 1 shared B. L. Hodges· 1 shared C. W. Vander Kooi· 1 shared D. Armstrong· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperBiochemistry

A. DePaoli-Roach

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Author profile →

3 papers

Recent·Most cited

An empirical pipeline for personalized diagnosis of Lafora disease mutations

M. K. Brewer, M. Machio-Castello, R. Viana, J. L. Wayne, A. Kuchtova, Z. R. Simmons, S. Sternbach, S. Li, M. A. Garcia-Gimeno, J. Serratosa, P. Sanz, C. W. Vander Kooi, M. S. Gentry

This paper develops an empirical pipeline to classify EPM2A mutations in Lafora disease by analyzing their functional impact in vitro, linking specific mutations to clinical outcomes.

bioRxiv · Mar 26, 2021Biochemistry

Lack of astrocytic glycogen alters synaptic plasticity but not seizure susceptibility

J. Duran, M. K. Brewer, A. Hervera, A. Gruart, J. A. del Rio, J. M. Delgado-Garcia, J. J. Guinovart

bioRxiv · May 6, 2020Biochemistry

Targeting pathogenic Lafora bodies in Lafora disease using an antibody-enzyme fusion

M. K. Brewer, A. Uittenbogaard, G. L. Austin, J. J. McCarthy, D. M. Segvich, A. DePaoli-Roach, P. J. Roach, B. L. Hodges, J. Zeller, J. R. Pauly, T. McKnight, D. Armstrong, M. Gentry

This paper develops an antibody-enzyme fusion that degrades Lafora bodies in a mouse model of Lafora disease, reducing LB load and showing therapeutic potential.

bioRxiv · Jun 21, 2019Biochemistry