The physical form of microbial ligands bypasses the need for dendritic cell migration to stimulate adaptive immunity
F. Borriello, R. Spreafico, V. Poli, J. Chou, N. Barrett, L. Lacanfora, M. Franco, L. Marongiu, Y. Iwakura, F. Pucci, M. Kruppa, Z. Ma, D. Williams, I. Zanoni
This study shows that soluble fungal polysaccharides are immunosilent in peripheral tissues but become potent immunogens in draining lymph nodes without requiring dendritic cell migration.
bioRxiv · Mar 3, 2020 · PreprintImmunology