R. Spreafico

Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter.

The paper shows host-derived oxidized phospholipids initiate effector-triggered immunity, leading to lethality upon microbial encounter, and demonstrates that blocking oxPLs reduces inflammation and host death.

Universal Amplicon Sequencing of North Imperial Valley Wetlands Microbiomes

The paper introduces a universal amplicon sequencing method for microbial communities and applies it to study wetlands, showing monthly microbial variation in the Salton Sea.

Robust and durable prophylactic protection conferred by RNA interference in preclinical models of SARS-CoV-2

This study identifies two siRNA combinations that provide robust prophylactic protection against SARS-CoV-2 in hamsters by reducing viral load and preventing lung pathology.

The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2

This paper evaluates the in vitro and in vivo efficacy of dual-action monoclonal antibodies VIR-7831 and VIR-7832 against SARS-CoV-2, showing potent neutralization and reduced viral load in a hamster model.

Maturation signatures of conventional dendritic cell subtypes in COVID-19 reflect direct viral sensing

This study identifies maturation signatures of conventional dendritic cell subtypes in COVID-19, showing that cDC2s exhibit viral sensing and inflammatory activation while losing antigen presentation capacity, correlating with disease severity.

The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity

The paper shows the N439K SARS-CoV-2 spike variant maintains replication fitness while evading antibody neutralization.

Type III interferons disrupt the lung epithelial barrier upon viral recognition.

This study shows that type III interferons from lung dendritic cells damage the epithelial barrier and increase susceptibility to bacterial infections during viral recognition.

Structural and functional analysis of a potent sarbecovirus neutralizing antibody

This study identifies and characterizes a potent neutralizing antibody, S309, against SARS-CoV-2 and related sarbecoviruses, showing its efficacy in preventing viral entry and potential for therapeutic use.

The physical form of microbial ligands bypasses the need for dendritic cell migration to stimulate adaptive immunity

This study shows that soluble fungal polysaccharides are immunosilent in peripheral tissues but become potent immunogens in draining lymph nodes without requiring dendritic cell migration.

Profiling immunoglobulin repertoires across multiple human tissues by RNA Sequencing

The paper develops ImReP, a computational method to profile TCR and BCR repertoires from RNA-seq data, creating a large atlas of immunological sequences across 53 tissues.