Author

M. L. Loh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Tsirigos· 1 shared B. Zhang· 1 shared C. G. Mullighan· 1 shared C. Smith· 1 shared C.-H. Pui· 1 shared D. Kuang· 1 shared F. Yue· 1 shared H. Mulder· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. Tsirigos

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2 papers

Recent·Most cited

NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization

S. Narang, N. Evensen, J. Saliba, J. Pierro, M. L. Loh, P. A. Brown, H. Mulder, Y. Shao, J. Easton, X. Ma, A. Tsirigos, W. L. Carroll

This study shows NSD2 E1099K mutation disrupts 3D chromatin organization in B-ALL, leading to drug resistance and clonal evolution through compartmentalization changes.

bioRxiv · Feb 24, 2022 · PreprintCancer Biology

Non-coding germline GATA3 variants alter chromatin topology and contribute to pathogenesis of acute lymphoblastic leukemia

H. Yang, H. Zhang, Y. Luan, T. Liu, K. G. Roberts, M.-x. Qian, B. Zhang, W. Yang, V. Perez-Andreu, J. Xu, S. Iyyanki, D. Kuang, S. C. Reshmi, J. Gastier-Foster, C. Smith, , J. J. Yang

The paper identifies a germline non-coding GATA3 variant that alters chromatin topology and contributes to Ph-like ALL by activating an enhancer and reshaping 3D genome organization.

bioRxiv · Feb 23, 2020 · PreprintCancer Biology