Author

C. G. Mullighan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:clustering· 2

Frequent Co-Authors

A. G. X. Zeng· 2 shared I. Iacobucci· 2 shared J. E. Dick· 2 shared Q. Gao· 2 shared S. Shah· 2 shared A. Advani· 1 shared A. J. Murison· 1 shared A. Mitchell· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. G. X. Zeng

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

KMT2A oncoproteins induce epigenetic resistance to targeted therapies

D. H. Janssens, M. Duran, D. J. Otto, W. Wu, Y. Xu, D. Kirkey, C. G. Mullighan, J. S. Yi, S. Meshinchi, J. F. Sarthy, K. Ahmad, S. Henikoff

This study shows KMT2A oncoproteins drive lineage-switching and epigenetic resistance in leukemia by dynamically binding chromatin and persisting as ENL-marked lesions despite therapy.

bioRxiv · Dec 29, 2023 · PreprintCancer Biology

Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML

A. G. X. Zeng, I. Iacobucci, S. Shah, A. Mitchell, G. Wong, S. Bansal, D. Chen, Q. Gao, H. Kim, J. A. Kennedy, M. D. Minden, T. Haferlach, C. G. Mullighan, J. E. Dick

The paper constructs a reference atlas of human hematopoiesis and maps AML differentiation patterns, revealing genetic and non-genetic factors driving aberrant differentiation in leukemia.

bioRxiv · Dec 26, 2023Cancer Biology

Single cell dissection of developmental origins and transcriptional heterogeneity in B-cell acute lymphoblastic leukemia

I. Iacobucci, A. G. X. Zeng, Q. Gao, L. Garcia-Prat, P. Baviskar, S. Shah, A. J. Murison, V. Voisin, M. Chan-Seng-Yue, C. Cheng, C. Qu, C. Bailey, M. Lear, M. Witkowski, X. Zhou, , C. G. Mullighan

This study uses scRNA-seq to analyze B-ALL samples, revealing transcriptional heterogeneity and developmental origins, with specific subtypes associated with distinct cell populations and clinical outcomes.

bioRxiv · Dec 4, 2023Cancer Biology

Non-coding germline GATA3 variants alter chromatin topology and contribute to pathogenesis of acute lymphoblastic leukemia

H. Yang, H. Zhang, Y. Luan, T. Liu, K. G. Roberts, M.-x. Qian, B. Zhang, W. Yang, V. Perez-Andreu, J. Xu, S. Iyyanki, D. Kuang, S. C. Reshmi, J. Gastier-Foster, C. Smith, , J. J. Yang

The paper identifies a germline non-coding GATA3 variant that alters chromatin topology and contributes to Ph-like ALL by activating an enhancer and reshaping 3D genome organization.

bioRxiv · Feb 23, 2020 · PreprintCancer Biology