Author

J. J. Yang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell-cell communication· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A. Brown· 3 shared C. Tian· 3 shared J. Yu· 3 shared L. Fan· 3 shared L. Li· 3 shared L. Zhu· 3 shared Q. Pan· 3 shared W. Yang· 3 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

A. Brown

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Spatiotemporal Dynamics of Vcam1 Regulates Cholangiocarcinoma Mass Expansion and Tumor Dissemination under Growth-suppressive Peritumoral Myofibroblasts

L. Zhu, C. Tian, L. Li, Q. Pan, B. Xu, y. li, L. Fan, A. Brown, M. Morrison, K. Dey, J. J. Yang, J. Yu, E. S. Glazer

This study shows that Vcam1 expression in cholangiocarcinoma cells is regulated by peritumoral myofibroblasts, promoting tumor dissemination while suppressing growth.

bioRxiv · Jan 24, 2023Cancer Biology

Exercise Training Remodels Adipocyte-Specific Extracellular Matrix Proteins and Alters Innervation and Vascularization in Inguinal White Adipose Tissue (iWAT)

P. Nigro, M. Vamvini, J. J. Yang, T. Caputo, L.-L. Ho, D. Papadopoulos, N. P. Carbone, R. Colin, J. He, H. F. Michael, J. D. White, J. Robidoux, R. Hickner, S. Nielsen, B. K. Pedersen, , L. J. Goodyear

This study shows that exercise training remodels iWAT ECM, increases vascularization and innervation, and alters adipocyte subpopulations in male mice.

bioRxiv · Aug 9, 2022Physiology

A Developmentally Prometastatic Niche to Hepatoblastoma in Neonatal Liver mediated by the Cxcl1/Cxcr2 Axis

L. Fan, Q. Pan, W. Yang, S. C. Koo, C. Tian, L. Li, M. Lu, A. Brown, B. Ju, J. Easton, S. Ranganathan, S. Shin, A. Bondoc, J. J. Yang, J. Yu, L. Zhu

This study identifies a neonatal liver niche that promotes hepatoblastoma metastasis via the Cxcl1/Cxcr2 axis, showing increased tumor aggressiveness and hypoxia in early postnatal models.

bioRxiv · Oct 22, 2021Cancer Biology

Paradoxical Roles of Peritumoral Myofibroblasts in Intrahepatic Cholangiocarcinoma Growth and Metastasis

L. Zhu, C. Tian, L. Li, Q. Pan, y. li, W. Yang, L. Fan, A. Brown, M. Morrison, K. M. Dey, E. J. Norris, J. J. Yang, J. Yu, E. S. Glazer

This study shows peritumoral myofibroblasts suppress iCCA growth but promote metastasis through Vcam1-dependent mechanisms.

bioRxiv · Feb 19, 2021 · PreprintCancer Biology

Understanding the origins of loss of protein function by analyzing the effects of thousands of variants on activity and abundance

M. Cagiada, K. E. Johansson, A. Valanciute, S. V. Nielsen, R. Hartmann-Petersen, J. J. Yang, D. M. Fowler, A. Stein, K. Lindorff-Larsen

The paper analyzes variant effects on protein activity and abundance in NUDT15 and PTEN, finding that a third of variants cause loss of function and half of these also reduce abundance.

bioRxiv · Sep 28, 2020Biophysics

Non-coding germline GATA3 variants alter chromatin topology and contribute to pathogenesis of acute lymphoblastic leukemia

H. Yang, H. Zhang, Y. Luan, T. Liu, K. G. Roberts, M.-x. Qian, B. Zhang, W. Yang, V. Perez-Andreu, J. Xu, S. Iyyanki, D. Kuang, S. C. Reshmi, J. Gastier-Foster, C. Smith, , J. J. Yang

The paper identifies a germline non-coding GATA3 variant that alters chromatin topology and contributes to Ph-like ALL by activating an enhancer and reshaping 3D genome organization.

bioRxiv · Feb 23, 2020 · PreprintCancer Biology