Author

Y. Luan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

W. Tang· 3 shared B. K. Rajendran· 2 shared D. Wu· 2 shared Q. Yuan· 2 shared Y. Liu· 2 shared A. Li· 1 shared B. Zhang· 1 shared C. Chen· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersImmunology

W. Tang

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Loss of WNT5 Proteins Reprograms Neutrophils in the Spleen to Provide Protection for DSS-Induced Colitis

Y. Luan, J. Hu, Q. Wang, W. Li, X. Wang, R. Qu, B. K. Rajendran, H. Zhou, P. Liu, Y. Shi, Y. Liu, J. Lu, W. Tang, D. Wu

This study shows that loss of WNT5A and WNT5B in mice protects against DSS-induced colitis by reprogramming spleen neutrophils to suppress inflammation.

bioRxiv · Jan 28, 2023 · PreprintImmunology

Lack of Fzd6 in Ciliated Cells Suppresses Ferroptotic Pulmonary Alveolar Cell Death Induced by LPS and Coronavirus

Q. Yuan, Y. Luan, B. K. Rajendran, S. Compton, W. Tang, D. Wu

This study shows that Fzd6 deficiency in ciliated cells reduces pulmonary inflammation-induced cell death by increasing Akr1b8 expression and protecting against ferroptosis.

bioRxiv · Jan 23, 2023 · PreprintPathology

LDL Receptor-Related Protein 5 is a Selective Transporter for Unesterified Polyunsaturated Fatty Acids

W. Tang, Y. Luan, Q. Yuan, A. Li, S. Chen, S. Menacherry, L. Young, D. D. Wu

This study identifies LRP5 as a selective transporter for unesterified PUFAs, showing its role in mTORC1 inhibition and protection against myocardial injury.

bioRxiv · Jan 16, 2023 · PreprintCell Biology

Histone demethylase UTX regulates glioblastoma progression through affecting periostin expression

Y. Luan, Y. Liu, J. Xue, K. Wang, K. Ma, H. Lu, X. Chen, Y. Liu, Z. Zhang

This study shows that UTX promotes glioblastoma progression by upregulating periostin expression, and its knockdown inhibits tumor growth and promotes apoptosis.

bioRxiv · Dec 17, 2021 · PreprintCancer Biology

Decoding regulatory specificity of human ribosomal proteins

Y. Luan, N. Tang, J. Yang, C. Chen, S. Liu, C. Cheng, Y. Wang, Y. Guo, H. Wang, M. Xiang, R. Ju, Z. Xie

This study shows that ribosomal protein (RP) deficiency affects gene expression through translational and transcriptional changes, with distinct impacts on cell growth, apoptosis, and development.

bioRxiv · Mar 27, 2021 · PreprintCell Biology

Non-coding germline GATA3 variants alter chromatin topology and contribute to pathogenesis of acute lymphoblastic leukemia

H. Yang, H. Zhang, Y. Luan, T. Liu, K. G. Roberts, M.-x. Qian, B. Zhang, W. Yang, V. Perez-Andreu, J. Xu, S. Iyyanki, D. Kuang, S. C. Reshmi, J. Gastier-Foster, C. Smith, , J. J. Yang

The paper identifies a germline non-coding GATA3 variant that alters chromatin topology and contributes to Ph-like ALL by activating an enhancer and reshaping 3D genome organization.

bioRxiv · Feb 23, 2020 · PreprintCancer Biology