Author

M. M. Falco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Assay:scRNA-seq· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Virtanen· 3 shared E. P. Erkan· 3 shared J. Hynninen· 3 shared J. Oikkonen· 3 shared S. Hautaniemi· 3 shared Y. Li· 3 shared A. Farkkila· 2 shared A. Vaharautio· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersCancer Biology

A. Virtanen

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Author profile →

4 papers

Recent·Most cited

Multi-Omics Analysis Reveals the Attenuation of the Interferon Pathway as a Driver of Chemo-Refractory Ovarian Cancer

D. Afenteva, R. Yu, A. Rajavuori, M. Salvadores, I.-M. Launonen, K. Lavikka, K. Zhang, G. Marchi, S. Jamalzadeh, V.-M. Isoviita, Y. Li, G. Micoli, E. P. Erkan, M. M. Falco, D. Ungureanu, , S. Hautaniemi

The paper identifies reduced IFN-I pathway activity as a driver of chemo-refractory ovarian cancer using multi-omics analysis in a clinical trial cohort.

bioRxiv · Mar 28, 2024Cancer Biology

Chemotherapy induces myeloid-driven spatial T-cell exhaustion in ovarian cancer

I.-M. P. Launonen, E. P. Erkan, I. Niemiec, A. Junquera, M. Hincapie-Otero, D. Afenteva, Z. Liang, M. Salko, A. Szabo, F. Perez-Villatoro, M. M. Falco, Y. Li, G. Micoli, A. Nagaraj, U.-M. Haltia, , A. Farkkila

This study shows chemotherapy causes myeloid-driven spatial T-cell exhaustion in ovarian cancer by altering immune cell states and interactions, suggesting new immunotherapy approaches.

bioRxiv · Mar 19, 2024 · PreprintCancer Biology

Tracing back primed resistance in cancer via sister cells

J. Dai, S. Zheng, M. M. Falco, J. Bao, J. Eriksson, S. Pikkusaari, S. Forsten, J. Jiang, W. Wang, L. Gao, F. Perez-Villatoro, O. Dufva, K. Saeed, Y. Wang, A. Amiryousefi, , A. Vähärautio

The paper introduces ReSisTrace, a method to identify pre-resistant cell states in cancer by analyzing sister cells, and validates its use in ovarian cancer models.

bioRxiv · Jul 6, 2022Cancer Biology

A platform for efficient establishment, expansion and drug response profiling of high-grade serous ovarian cancer organoids

W. Senkowski, L. Gall-Mas, M. M. Falco, Y. Li, K. Lavikka, M. C. Kriegbaum, J. Oikkonen, D. Bulanova, E. J. Pietras, K. Vossgröne, Y.-J. Chen, E. P. Erkan, M. K. Gronning Hog, I. M. Larsen, T. Lamminen, , K. Wennerberg

This paper describes a method to generate and expand high-grade serous ovarian cancer organoids with improved success rates and reports their drug response correlation with clinical outcomes.

bioRxiv · Apr 21, 2022Cancer Biology