Y.-J. Chen

The non-mitotic role of HMMR in regulating the localization of TPX2 and the dynamics of microtubules in neurons

This study investigates HMMR's non-mitotic role in regulating TPX2 localization and microtubule dynamics in neurons, revealing its impact on neuronal morphology.

Identifying perturbations that boost T-cell infiltration into tumours via counterfactual learning of their spatial proteomic profiles

The paper develops a deep-learning model to identify minimal tumour perturbations that enhance T-cell infiltration using spatial proteomic data from cancer samples.

Membrane Protein Modification Modulates Big and Small Extracellular Vesicle Biodistribution and Tumorigenic Potential in Breast Cancers In Vivo

This study identifies distinct in vivo properties and functions of large and small extracellular vesicles in breast cancer, showing their differential biodistribution and tumorigenic potential.

Computational design of peptides to target Nav1.7 channel with high potency and selectivity for the treatment of pain

The paper designs potent and selective peptide inhibitors of human NaV1.7 channels using Rosetta, with two peptides showing sub-nanomolar IC50 and high selectivity over other sodium channels.

An atypical F-actin capping protein modulates cytoskeleton behaviors crucial to colonization of Trichomonas vaginalis

This study identifies an atypical F-actin capping protein in Trichomonas vaginalis that modulates cytoskeleton dynamics through phosphorylation, essential for host colonization.

A platform for efficient establishment, expansion and drug response profiling of high-grade serous ovarian cancer organoids

This paper describes a method to generate and expand high-grade serous ovarian cancer organoids with improved success rates and reports their drug response correlation with clinical outcomes.

Molecular hydrogen is an overlooked energy source for marine bacteria

This study shows marine bacteria consume molecular hydrogen as an energy source, with H2 oxidation more active in subantarctic waters and supported by genomic and experimental evidence.

A nanopore interface for high bandwidth DNA computing

This paper introduces a nanopore-based readout method for DNA strand displacement circuits, achieving higher output bandwidth than fluorescence spectroscopy for molecular diagnostics.

Electrochemical biosensors based on peptide-kinase interactions at the kinase docking site

The paper develops electrochemical biosensors that detect kinases by measuring interactions at their docking sites, demonstrating high selectivity for ERK2 over other kinases and proteins.

Whole blood metabolomics of dementia patients reveal classes of disease-linked metabolites

This study identifies 5 groups of blood metabolites associated with dementia, 21 of which are novel, suggesting potential diagnostic and therapeutic targets.

Identification of Novel Genetic Susceptibility Loci for Thoracic and Abdominal Aortic Aneurysms Via Genome-Wide Association Study Using the UK Biobank Cohort

This paper identifies novel genetic loci for thoracic and abdominal aortic aneurysms using GWAS in the UK Biobank and finds distinct genetic architectures and shared pathophysiology with Marfan syndrome.

Metabolic flexibility allows generalist bacteria to become dominant in a frequently disturbed ecosystem

This study shows that metabolically flexible bacteria dominate in disturbed ecosystems, outcompeting specialists during habitat disturbance.

GenOrigin: A Comprehensive Protein-coding Gene Origination Database on the Evolutionary Timescale of Life

GenOrigin systematically dates the age of 9.1 million protein-coding genes across 565 species and provides a database for gene age estimates and functional annotations.

Content-Based Similarity Search in Large-Scale DNA Data Storage Systems

The paper demonstrates content-based image similarity search using a database of 1.6 million images encoded in synthetic DNA, achieving retrieval rates greater than chance.

Systemic Bone Loss Following Myocardial Infarction in Mice is Mitigated by Treatment with a β3 Adrenergic Receptor Antagonist

This study shows that myocardial infarction causes systemic bone loss in mice, which is partially prevented by β3-adrenergic receptor antagonist treatment.

Distinct life histories impact dikaryotic genome evolution in the rust fungus Puccinia striiformis causing stripe rust in wheat

This study compares two isolates of the wheat rust fungus Puccinia striiformis with different life histories, finding that long-term asexual evolution leads to genome expansion, transposable element accumulation, and increased heterozygosity.

Two Chloroflexi classes independently evolved the ability to persist on atmospheric hydrogen and carbon monoxide

This study shows two Chloroflexi classes can persist using atmospheric hydrogen and carbon monoxide as energy sources through horizontal gene transfer.

Glucose intake hampers PKA-regulated HSP90 chaperone activity

The paper identifies Ids2 as a regulator of HSP90 chaperone activity, showing that glucose intake inhibits its function, linking nutrient sensing to proteostasis and longevity.

Scaling up DNA data storage and randomaccess retrieval

This paper demonstrates large-scale DNA data storage with random access, storing 200MB of data in 13 million DNA oligonucleotides and achieving error-free retrieval.