Author

O. Dufva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:statistical model· 4 Approach:deep learning· 3 Research Focus:gene regulatory network inference· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

S. Mustjoki· 3 shared K. Saeed· 2 shared A. Amiryousefi· 1 shared A. Färkkilä· 1 shared a. horowitz· 1 shared A. Kumar· 1 shared A. Maurer· 1 shared A. Näätänen· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

S. Mustjoki

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping

H. K. Netskar, A. Pfefferle, J. P. Goodridge, E. Sohlberg, O. Dufva, S. Teichmann, T. Clancy, a. horowitz, K.-J. Malmberg

The paper creates a single-cell reference map of NK cells and identifies tumor-associated states predictive of patient outcomes in melanoma and osteosarcoma.

bioRxiv · Oct 26, 2023Immunology

Single-cell functional genomics of natural killer cell evasion in blood cancers

O. Dufva, S. Gandolfi, J. Huuhtanen, O. Dashevsky, K. Saeed, J. Klievink, P. Nygren, J. Bouhlal, J. Lahtela, A. Näätänen, B. Ghimire, T. Hannunen, P. Ellonen, H. Duan, J. Theodoropoulos, , S. Mustjoki

The paper uses single-cell and genome-scale functional genomics to study how blood cancer cells evade NK cells, identifying key genes and pathways involved in resistance and sensitivity.

bioRxiv · Aug 22, 2022 · PreprintImmunology

Tracing back primed resistance in cancer via sister cells

J. Dai, S. Zheng, M. M. Falco, J. Bao, J. Eriksson, S. Pikkusaari, S. Forsten, J. Jiang, W. Wang, L. Gao, F. Perez-Villatoro, O. Dufva, K. Saeed, Y. Wang, A. Amiryousefi, , A. Vähärautio

The paper introduces ReSisTrace, a method to identify pre-resistant cell states in cancer by analyzing sister cells, and validates its use in ovarian cancer models.

bioRxiv · Jul 6, 2022Cancer Biology

Nintedanib Targets KIT D816V Neoplastic Cells Derived from Induced Pluripotent Stem cells of Systemic Mastocytosis

M. A. Szymanski de Toledo, M. Gatz, S. Sontag, K. V. Gleixer, G. Eisenwort, K. Feldberg, F. Kluge, R. Guareschi, G. Rossetti, A. S. Sechi, O. Dufva, S. M. Mustjoki, A. Maurer, H. M. Schueler, R. Goetzke, , M. Zenke

This study identifies nintedanib as a novel KIT D816V inhibitor effective against patient-derived neoplastic mast cells in systemic mastocytosis.

bioRxiv · May 6, 2020Cancer Biology

Immunogenomic landscape of hematological malignancies

O. Dufva, P. Polonen, O. Bruck, M. Keranen, J. Mehtonen, A. Kumar, C. Heckman, S. Siitonen, K. Granberg, S.-K. Leivonen, L. Meriranta, S. Leppa, M. Nykter, O. Lohi, M. Heinaniemi, S. Mustjoki

This study links immunological features to cancer subtypes, genetic alterations, and patient survival in hematological malignancies using integrated genomic and transcriptomic data.

bioRxiv · Apr 26, 2019Immunology