Mammary lineage dictates homologous recombination repair and PARP inhibitor vulnerability
H. Kim, A. E. Casey, L. Palomero, M. Mahendralingam, M. Parsons, S. Narala, F. Mateo, S. Hofer, P. D. Waterhouse, T. Kislinger, M. A. Pujana, H. K. Berman, R. Khokha
The paper shows that mammary epithelial lineage determines HR and PARP inhibitor vulnerability, with luminal cells having high-fidelity HR and PARPi sensitivity.
bioRxiv · May 14, 2021 · PreprintCancer Biology