R. Khokha

Metabolic shift to serine pathway induced by lipids confers oncogenic properties in non-transformed breast cells

The paper shows that lipid metabolism, specifically through OA, shifts metabolic pathways in breast cells, increasing SAM and 2-HG, which contribute to oncogenic properties and epigenetic changes.

FABP7 Progenitors are a Targetable Metabolic Root in the BRCA1 Breast

This study identifies FABP7 progenitors as a targetable metabolic root in BRCA1 breast cancer, showing their dysregulation and potential inhibition via fatty acid metabolism disruption.

Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response via AP1 dichotomy in pancreatic cancer

The paper identifies AP1 transcription factor dichotomy and CD68+ macrophages as drivers of intratumoral subtype co-existence and therapy response in pancreatic cancer.

Droplet based low input proteomic platform for rare cell populations

DROPPS enables high-fidelity proteomic profiling of rare cell populations with low input, revealing CD36 as a marker of progenitor capacity in mammary basal cells.

Hourglass, a tool to mine bioimaging data, uncovers sex-disparities in the IL-6-associated T cell response in pancreatic tumors

Hourglass processes bioimaging data to reveal sex-specific IL-6 effects on T cell responses in pancreatic tumors.

Glycoproteomics Identifies Plexin-B3 as Targetable Cell Surface Protein Required for Growth and Invasion of Triple Negative Breast Cancer Cells

This study identifies Plexin-B3 as a cell surface protein essential for TNBC growth and invasion, using glycoproteomics and functional validation.

Mammary lineage dictates homologous recombination repair and PARP inhibitor vulnerability

The paper shows that mammary epithelial lineage determines HR and PARP inhibitor vulnerability, with luminal cells having high-fidelity HR and PARPi sensitivity.

Spatially confined sub-tumor microenvironments orchestrate pancreatic cancer pathobiology

This study identifies spatially confined sub-tumor microenvironments in PDAC that drive distinct tumor progression outcomes.

Mammary epithelial cells have lineage-restricted metabolic identities

The paper identifies lineage-restricted metabolic identities in normal mammary epithelial cells and links them to breast cancer metabolic heterogeneity.