Author

C. J. Eaves

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:clustering· 2

Frequent Co-Authors

C. Hammond· 2 shared D. Pellacani· 2 shared M. Hirst· 2 shared A. Bagchi· 1 shared A. Deshpande· 1 shared A. E. Casey· 1 shared A. El-Naggar· 1 shared A. Koren· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersImmunology

C. Hammond

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Author profile →

5 papers

Recent·Most cited

Human lymphoid-neutrophil/monocyte restriction co-ordinately activates increased proliferation despite parallel heterogeneity in transcriptional changes

F. Wang, L. G. Campos, C. Hammond, M. Hirst, B. D. Simons, C. J. Eaves

The paper identifies shared proliferation acceleration and heterogeneous transcriptional changes during B-lymphoid and neutrophil/monocyte lineage restriction from CD34+ cord blood cells.

bioRxiv · Feb 18, 2024 · PreprintImmunology

YB-1 IS REQUIRED FOR THE GENESIS AND METASTATIC CAPACITY OF HUMAN BREAST CANCER

S. Lefort, A. El-Naggar, S. Tan, S. Colborne, G. L. Negri, D. Pellacani, M. Hirst, B. Gusterson, G. B. Morin, P. H. Sorensen, C. J. Eaves

This study shows YB-1 is essential for human breast cancer growth and metastasis, as its knockdown inhibits tumor formation and lung colonization in mice.

bioRxiv · Nov 20, 2020 · PreprintCancer Biology

A JAK/STAT-Mediated Inflammatory Signaling Cascade Drives Oncogenesis In AF10-Rearranged AML

B. Chen, A. Deshpande, K. O. Barbosa, M. Kleppe, X. Lei, N. Yeddula, A. Rosa Campos, R. Wechsler-Reya, A. Bagchi, S. Meshinchi, C. J. Eaves, I. Jeremias, T. Haferlach, D. Frank, Z. Ronai, , A. Deshpande

This study identifies JAK1 as a therapeutic target in AF10-rearranged AML by showing its role in JAK/STAT-mediated inflammatory signaling and oncogenesis.

bioRxiv · Aug 31, 2020Cancer Biology

Mammary epithelial cells have lineage-restricted metabolic identities

M. Mahendralingam, K. Aliar, A. E. Casey, D. Pellacani, H. Kim, V. Ignatchenko, M. G. Valero, L. Palomero, A. Sinha, V. Stambolic, M. Alam, A. Schimmer, H. Berman, M. A. Pujana, C. J. Eaves, , R. Khokha

The paper identifies lineage-restricted metabolic identities in normal mammary epithelial cells and links them to breast cancer metabolic heterogeneity.

bioRxiv · Oct 8, 2019Cell Biology

Replication timing alterations in leukemia reflect stable clinically-relevant changes in genome architecture

J. C. Rivera-Mulia, T. Sasaki, C. Trevilla-Garcia, N. Nakamichi, D. J. H. F. Knapp, C. Hammond, B. Chang, J. W. Tyner, M. Devidas, J. Zimmerman, K. Klein, V. Somasundaram, B. Druker, T. Gruber, A. Koren, , D. M. Gilbert

The paper compares DNA replication timing profiles of BCP-ALL leukemic samples with normal B-lineage differentiation stages to identify clinically relevant features.

bioRxiv · Apr 11, 2019 · PreprintCancer Biology