Author

M. McLaren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:cryo-EM· 5 Research Focus:protein structure prediction· 5 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Approach:microscopy & imaging analysis· 2 Organism:C. elegans· 1

Frequent Co-Authors

B. Daum· 8 shared V. Gold· 6 shared M. N. Isupov· 4 shared R. Conners· 4 shared K. Sanders· 3 shared L. Gambelli· 3 shared C. Hanus· 2 shared J. Rakonjac· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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8 shared papersMicrobiology

B. Daum

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

CryoEM reveals the structure of an archaeal pilus involved in twitching motility

M. C. Gaines, S. Sivabalasarma, M. N. Isupov, R. U. Haque, M. McLaren, C. Hanus, V. A. M. Gold, S.-V. Albers, B. Daum

The paper presents a cryoEM structure of the archaeal adhesive pilus (Aap) from Sulfolobus acidocaldarius, revealing three distinct conformations of the subunit AapB.

bioRxiv · Aug 7, 2023Microbiology

The consequence of ATP synthase dimer angle on mitochondrial morphology studied by cryo-electron tomography

E. Buzzard, M. McLaren, P. Bragoszewski, A. Brancaccio, H. Ford, B. Daum, P. Kuwabara, I. Collinson, V. Gold

The paper uses cryo-electron tomography to study ATP synthase dimer angles in C. elegans and compares them to yeast, revealing differences in mitochondrial morphology and potential functional implications.

bioRxiv · Feb 2, 2023Biochemistry

Cryo-electron microscopy of the f1 filamentous phage reveals a new paradigm in viral infection and assembly

R. Conners, R. I. Leon-Quezada, M. McLaren, N. Bennett, B. Daum, J. Rakonjac, V. Gold

The paper determines the structure of a filamentous phage using cryo-electron microscopy and identifies key domains involved in infection and assembly.

bioRxiv · Nov 3, 2022Microbiology

Structure of the two-component S-layer of the archaeon Sulfolobus acidocaldarius

L. Gambelli, M. McLaren, R. Conners, K. Sanders, M. C. Gaines, L. Clark, V. Gold, D. Kattnig, M. Sikora, C. Hanus, M. N. Isupov, B. Daum

The paper determines the atomic structure of the two-component S-layer in Sulfolobus acidocaldarius using cryoEM, cryoET, and AlphaFold2.

bioRxiv · Oct 7, 2022Microbiology

Donor strand complementation, isopeptide bonds and glycosylation stabilise highly resilient archaeal thread filaments

M. Gaines, M. N. Isupov, S. Sivabalasarma, R. U. Haque, M. McLaren, P. Tripp, A. Neuhaus, V. Gold, S.-V. Albers, B. Daum

The paper identifies and characterizes the structure of archaeal thread filaments, revealing their stabilization through glycosylation, donor strand complementation, and isopeptide bonds.

bioRxiv · Apr 26, 2022Microbiology

New insights into the architecture and dynamics of archaella

L. Gambelli, M. N. Isupov, R. Conners, M. McLaren, A. Bellack, V. Gold, R. Rachel, B. Daum

The paper presents the structure of the Methanocaldococcus villosus archaellum filament, revealing it is composed of two alternating archaellins and contains structural elements that enable movement.

bioRxiv · Oct 1, 2021 · PreprintMicrobiology

CryoEM structure of the outer membrane secretin channel pIV from the f1 filamentous bacteriophage

R. Conners, M. McLaren, U. Lapinska, K. Sanders, M. R. L. Stone, M. A. T. Blaskovich, S. Pagliara, B. Daum, J. Rakonjac, V. A. M. Gold

The paper determines the cryo-EM structure of the phage secretin pIV from f1 bacteriophage, models its function, and compares it to bacterial secretins.

bioRxiv · Jul 20, 2021Biophysics

Architecture and modular assembly of Sulfolobus S-layers revealed by electron cryo-tomography

L. Gambelli, B. Meyer, M. McLaren, K. Sanders, T. E. F. Quax, V. Gold, S. V. Albers, B. Daum

This study uses electron cryo-microscopy to reveal the 3D architecture and modular assembly of S-layers in Sulfolobus strains, identifying subunits and proposing an assembly model.

bioRxiv · Jun 25, 2019Microbiology