Author

S. Sivabalasarma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Organism:multiple species· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:cryo-EM· 1

Frequent Co-Authors

S.-V. Albers· 7 shared P. Nussbaum· 3 shared B. Daum· 2 shared M. McLaren· 2 shared M. N. Isupov· 2 shared R. U. Haque· 2 shared A. M. Enkerlin· 1 shared A. Neuhaus· 1 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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7 shared papersMicrobiology

S.-V. Albers

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Archaeal type six secretion system mediates contact-dependent antagonism

T. Zachs, J. J. L. Malit, J. Xu, A. Schürch, S. Sivabalasarma, P. Nussbaum, S.-V. Albers, M. Pilhofer

The paper identifies a contact-dependent antagonism mechanism in archaea mediated by a CIS similar to bacterial T6SSs, revealing its role in shaping microbial communities.

Science Advances · Nov 15, 2024Peer-reviewedMicrobiology

The second messenger c-di-AMP controls natural competence via ComFB signaling protein

S. Samir, S. Doello, E. Zimmer, M. Haffner, A. M. Enkerlin, T. Mueller, L. Dengler, S. P. Lambidis, S. Sivabalasarma, S.-V. Albers, K. A. Selim

The paper shows that c-di-AMP regulates natural competence in cyanobacteria via the ComFB signaling protein, which is essential for pilus biogenesis and DNA uptake.

bioRxiv · Nov 27, 2023Microbiology

CryoEM reveals the structure of an archaeal pilus involved in twitching motility

M. C. Gaines, S. Sivabalasarma, M. N. Isupov, R. U. Haque, M. McLaren, C. Hanus, V. A. M. Gold, S.-V. Albers, B. Daum

The paper presents a cryoEM structure of the archaeal adhesive pilus (Aap) from Sulfolobus acidocaldarius, revealing three distinct conformations of the subunit AapB.

bioRxiv · Aug 7, 2023Microbiology

Archaeal self-activating GPN-loop GTPases involve a lock-switch-rock mechanism for GTP hydrolysis

L. Korf, X. Ye, M. S. Vogt, W. Steinchen, M. Watad, M. Tourte, S. Sivabalasarma, S.-V. Albers, L.-O. Essen

This paper investigates the structural dynamics of archaeal GPN-loop GTPases, revealing a lock-switch-rock mechanism for GTP hydrolysis and its functional impact on archaeal motility.

bioRxiv · Apr 8, 2023 · PreprintBiochemistry

Archaeal type IV pili stabilize Haloferax volcanii biofilms in flow

P. Odermatt, P. Nussbaum, S. Monnappa, L. Tala, Z. Li, S. Sivabalasarma, S.-V. Albers, A. Persat

This study shows that type IV pili in Haloferax volcanii are essential for biofilm stability under flow, with PilA2 sufficient for normal biofilm structure.

bioRxiv · Jan 20, 2023 · PreprintMicrobiology

Donor strand complementation, isopeptide bonds and glycosylation stabilise highly resilient archaeal thread filaments

M. Gaines, M. N. Isupov, S. Sivabalasarma, R. U. Haque, M. McLaren, P. Tripp, A. Neuhaus, V. Gold, S.-V. Albers, B. Daum

The paper identifies and characterizes the structure of archaeal thread filaments, revealing their stabilization through glycosylation, donor strand complementation, and isopeptide bonds.

bioRxiv · Apr 26, 2022Microbiology

Analysis of cell-cell bridges in Haloferax volcanii using Electron cryo-tomography reveal a continuous cytoplasm and S-layer

S. Sivabalasarma, H. Wetzel, P. Nussbaum, C. van der Does, M. Beeby, S.-V. Albers

The paper uses electron cryo-tomography and fluorescence microscopy to study cell-cell bridges in Haloferax volcanii, revealing a continuous cytoplasm and S-layer enveloping the bridges.

bioRxiv · Sep 30, 2020Microbiology