A. Kennedy

Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80 / PD-L1 interaction

This paper shows that rigid, bivalent CTLA-4 binding to CD80 disrupts the cis CD80/PD-L1 interaction, promoting PD-L1 availability through orientation and cross-linking.

Biosynthesis of Arcyriaflavin F from Streptomyces venezuelae ATCC 10712

This paper reports a new indolocarbazole biosynthetic pathway in Streptomyces venezuelae and identifies a regioselective C-5 hydroxylating enzyme.

Development of MHC Class I Blocking Peptides to Target Metabolic Dysfunction-Associated Steatohepatitis CD8+ T Cell Activation

The paper develops MHC class I blocking peptides to inhibit CD8+ T cell activation in MASH, reducing inflammation and fibrosis.

The MYCN 5' UTR as a therapeutic target in neuroblastoma

This study investigates the therapeutic potential of targeting eIF4A1 to inhibit MYCN expression in neuroblastoma by exploiting its role in translation of polypurine-rich 5' UTRs.

Wild bird mass mortalities in eastern Canada associated with the Highly Pathogenic Avian Influenza A(H5N1) virus, 2022

The paper estimates 40,966 wild bird mortalities in eastern Canada due to H5N1 avian influenza in 2022, highlighting potential population-level impacts on Northern Gannets and American Common Eiders.

Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and aging

This study identifies how DNMT3A and TET2 mutations in hematopoietic stem cells confer a selective advantage by reducing inflammation and aging effects.

Early Life Exposure to Queen Mandibular Pheromone Mediates Persistent Transcriptional Changes in the Brain of Honey bee Foragers

This study shows that early exposure to queen mandibular pheromone in honey bees leads to long-term transcriptional changes in brain and sensory tissues, affecting division of labor, learning, and aging, but not foraging activity.

CTLA-4 regulates PD-L1-PD-1 interactions via transendocytosis of CD80

The paper investigates how CTLA-4 regulates PD-L1-PD-1 interactions through CD80 transendocytosis, showing that CD80 removal enables PD-L1 recovery and that CTLA-4's cytoplasmic domain is essential for this process.

SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion

This study shows SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion by altering its structure and function.

Use of waggle dance information in honey bees is linked to gene expression in the antennae, but not in the brain

The study finds that gene expression in honey bee antennae, not the brain, is linked to the use of social information from waggle dances, with differences in dopamine and odor perception genes.

Genome-wide analysis of MIKC-type MADS-box genes in wheat: pervasive duplications may have facilitated adaptation to different environmental conditions

The paper analyzes MIKC-type MADS-box genes in wheat, finding their expansion and functional diversity may aid adaptation to environmental conditions.