Author

L. Picard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:gene regulatory network inference· 2 Approach:deep learning· 1

Frequent Co-Authors

A. CIMARELLI· 3 shared L. Etienne· 3 shared L. Gueguen· 2 shared A. Graczyk-Jarzynka· 1 shared A. J. Birkett· 1 shared A. J. R. Cooper· 1 shared A. Kumar· 1 shared A. Kusowska· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersEvolutionary Biology

A. CIMARELLI

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody Clonotype

J. R. Barrett, D. Pipini, N. D. Wright, A. J. R. Cooper, G. Gorini, D. Quinkert, A. M. Lias, H. Davies, C. Rigby, M. Aleshnick, B. G. Williams, W. J. Bradshaw, N. G. Paterson, T. Martinson, P. Kirtley, , S. J. Draper

The paper characterizes human antibodies against PfRH5, identifies key features of potent inhibitors, and demonstrates their prophylactic potential against malaria.

Cell · Sep 1, 2024Peer-reviewedImmunology

Ammonia inhibits antitumor activity of NK cells by decreasing mature perforin

M. Winiarska, J. Domagala, T. M. Grzywa, I. Baranowska, A. Kusowska, K. Fidyt, K. Marhelava, Z. Pilch, A. Graczyk-Jarzynka, L. Picard, K. Jastrzebski, M. Granica, M. Justyniarska, D. Urlaub, M. Bobrowicz, , C. Watzl

This study shows ammonia reduces NK cell antitumor activity by decreasing mature perforin levels in the tumor microenvironment.

bioRxiv · Nov 20, 2023 · PreprintCancer Biology

Trim69 is a microtubule regulator that acts as a pantropic viral inhibitor

Y. Song, X.-N. Nguyen, A. Kumar, C. da Silva, L. Picard, L. Etienne, A. CIMARELLI

The paper identifies Trim69 as a microtubule regulator that inhibits multiple viruses by stabilizing microtubules in IFN-stimulated myeloid cells.

bioRxiv · Jun 20, 2022Microbiology

Distinct evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates identify important host determinants of COVID-19

M. Cariou, L. Picard, L. Gueguen, S. Jacquet, A. Cimarelli, O. I. Fregoso, A. Molaro, V. Navratil, L. Etienne

This paper identifies evolutionary adaptations in SARS-CoV-2 interacting proteins in bats and primates, revealing host-specific determinants of viral susceptibility and COVID-19 severity.

bioRxiv · Apr 7, 2022Evolutionary Biology

DGINN, an automated and highly-flexible pipeline for the Detection of Genetic INNovations on protein-coding genes

L. Picard, Q. Ganivet, O. Allatif, A. Cimarelli, L. Gueguen, L. Etienne

DGINN automates the detection of genetic innovations and adaptive evolution in protein-coding genes using multiple methods and validates it on primate genes.

bioRxiv · Feb 25, 2020Evolutionary Biology