Author

M. Minczuk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. A. Powell· 2 shared A. Von Kriegsheim· 1 shared B. J. McCann· 1 shared C. Frezza· 1 shared C. Garone· 1 shared D. Bansal· 1 shared D. G. Ryan· 1 shared E. A. Miska· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

C. A. Powell

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Author profile →

3 papers

Recent·Most cited

mtFociCounter for automated single-cell mitochondrial nucleoid quantification and reproducible focianalysis

T. Rey, L. C. Tabara, J. Prudent, M. Minczuk

mtFociCounter quantifies mitochondrial nucleoids in single cells, revealing cell-to-cell heterogeneity and showing correlation between nucleoid number and mitochondrial area.

bioRxiv · Aug 13, 2022Cell Biology

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

D. G. Ryan, M. Yang, H. A. Prag, G. R. Blanco, E. Nikitopoulou, M. Segarra-Mondejar, C. A. Powell, T. Young, N. Burger, J. L. Miljkovic, M. Minczuk, M. P. Murphy, A. Von Kriegsheim, C. Frezza

This study investigates the effects of TCA cycle inhibition on redox and amino acid metabolism, revealing ATF4-dependent metabolic rewiring and distinct responses between FH and SDH inhibition.

bioRxiv · Jul 27, 2021Biochemistry

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs

L. Van Haute, S.-Y. Lee, B. J. McCann, C. A. Powell, D. Bansal, C. Garone, S. Shin, J.-S. Kim, M. Frye, J. G. Gleeson, E. A. Miska, H.-W. Rhee, M. Minczuk

This study identifies NSUN2 as a methyltransferase introducing 5-methylcytosine in mitochondrial tRNAs and shows its necessity for m5C modification but not for tRNA stability or oxidative phosphorylation in differentiated cells.

bioRxiv · May 3, 2019Biochemistry