Author

D. G. Ryan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2

Frequent Co-Authors

C. Frezza· 3 shared E. Nikitopoulou· 3 shared M. Yang· 3 shared A. Von Kriegsheim· 2 shared L. A. O'Neill· 2 shared L. Tronci· 2 shared M. P. Murphy· 2 shared T. Young· 2 shared

Activity by Year

2021-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersImmunology

C. Frezza

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Macrophage Innate Training Induced by IL-4 and IL-13 Activation Enhances OXPHOS Driven Anti-Mycobacterial Responses

M. L. Lundahl, M. Mitermite, D. G. Ryan, S. Case, N. C. Williams, M. Yang, R. I. Lynch, E. Lagan, F. M. Lebre, A. L. Gorman, B. Stojkovic, A. P. Bracken, C. Frezza, F. J. Sheedy, E. M. Scanlan, , E. C. Lavelle

This study shows that IL-4 and IL-13 activation of macrophages induces protective innate memory against mycobacterial infection through enhanced OXPHOS-driven pro-inflammatory responses.

bioRxiv · Oct 12, 2021Immunology

Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression

M. Sciacovelli, A. Dugourd, L. Valcarcel Jimenez, M. Yang, E. Nikitopoulou, A. S. Costa, L. Tronci, V. Caraffini, P. Rodrigues, C. Schmidt, D. G. Ryan, T. Young, V. Zecchini, S. H. Rossi, C. Massie, , C. Frezza

This study identifies metabolic reprogramming in renal cancer cells, showing how branched-chain amino acid catabolism and urea cycle enzymes support tumor progression and metastasis.

bioRxiv · Sep 17, 2021 · PreprintCancer Biology

Nrf2 is a central regulator of the metabolic landscape in macrophages and finetunes their inflammatory response

D. G. Ryan, E. V. Knatko, A. Casey, J. L. Hukelmann, A. J. Brenes, S. Dayalan Naidu, M. Higgins, L. Tronci, E. Nikitopoulou, L. A. O'Neill, A. I. Lamond, A. Y. Abramov, D. A. Cantrell, M. P. Murphy, A. T. Dinkova-Kostova

This study shows Nrf2 regulates macrophage metabolism, redox balance, and inflammatory responses, with 4-OI modulating these effects through Nrf2.

bioRxiv · Aug 13, 2021 · PreprintImmunology

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

D. G. Ryan, M. Yang, H. A. Prag, G. R. Blanco, E. Nikitopoulou, M. Segarra-Mondejar, C. A. Powell, T. Young, N. Burger, J. L. Miljkovic, M. Minczuk, M. P. Murphy, A. Von Kriegsheim, C. Frezza

This study investigates the effects of TCA cycle inhibition on redox and amino acid metabolism, revealing ATF4-dependent metabolic rewiring and distinct responses between FH and SDH inhibition.

bioRxiv · Jul 27, 2021Biochemistry