E. A. Miska

Canalisation and plasticity on the developmental manifold of Caenorhabditis elegans

The paper explores how developmental robustness and plasticity coexist in C. elegans by analyzing growth and developmental data across genetic and environmental contexts.

Ecological speciation promoted by divergent regulation of functional genes within African cichlid fishes

The paper investigates transcriptome divergence in African cichlid fishes, identifying regulatory variants contributing to ecological speciation through differential gene expression and splicing.

Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state

This study shows that RTKs form liquid-liquid phase-separated states with downstream effectors to enhance signaling fidelity.

Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA

The paper identifies reader proteins for 5-methylcytosine and its derivatives in C. elegans RNA using modified RNA baits and mass spectrometry.

MOV10 facilitates messenger RNA decay in an N6-methyladenosine (m6A) dependent manner to maintain the mouse embryonic stem cells state

The paper identifies MOV10 as a new m6A-reader that facilitates mRNA decay via m6A to regulate the WNT/β-CATENIN pathway and maintain mouse embryonic stem cell state.

Differential use of multiple genetic sex determination systems in divergent ecomorphs of an African crater lake cichlid

The paper identifies three coexisting sex-determining alleles in two ecomorphs of Astatotilapia calliptera, showing genetic interactions affecting fitness and speciation.

Visualising formation of the ribosomal active site in mitochondria

The paper uses cryo-electron microscopy to visualize mitoribosome biogenesis, showing how GTPBP7 and NSUN4/MTERF4 regulate PTC formation and mitochondrial function.

The Orsay Virus as a model for population-wide viral infection dynamics

This paper uses C. elegans infected with Orsay Virus to study population-wide viral infection dynamics, showing host genetics and behavior influence viral spread.

Evolutionary divergence of novel open reading frames in cichlids speciation

This study identifies and analyzes novel open reading frames (nORFs) in two cichlid species, suggesting their potential role in speciation and evolutionary divergence.

Ancestral hybridisation facilitated species diversification in the Lake Malawi cichlid fish adaptive radiation

This study shows ancestral hybridisation contributed to diversification in Lake Malawi cichlids by introducing genetic variation that was differentially selected during speciation.

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs

This study identifies NSUN2 as a methyltransferase introducing 5-methylcytosine in mitochondrial tRNAs and shows its necessity for m5C modification but not for tRNA stability or oxidative phosphorylation in differentiated cells.

Direct interaction of PIWI and DEPS-1 is essential for piRNA function and condensate ultrastructure in Caenorhabditis elegans

The paper investigates how PIWI and DEPS-1 interact to support piRNA function and condensate structure in C. elegans.

Whole genome sequences of Malawi cichlids reveal multiple radiations interconnected by gene flow

The study sequenced 73 Lake Malawi cichlid species to reveal evolutionary processes driving adaptive radiation and gene flow between lineages.

Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements

The paper analyzes piRNA pathways across 20 arthropod species, finding somatic piRNAs as an ancestral defense against transposable elements.

An alternative STAT signaling pathway acts in antiviral immunity in Caenorhabditis elegans

The paper identifies a novel STAT signaling pathway in C. elegans that suppresses antiviral immunity, contrasting with the mammalian interferon system.